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Summary of Significant Accounting Policies - Loss per share, Warrants and Options expirations (Details) - $ / shares
12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]      
Securities excluded 9,559,368 355,542  
Weighted average exercise price, outstanding options $ 5.73 $ 27.56 $ 37.12
Common stock purchase warrants      
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]      
Securities excluded 6,538,073 667  
Employee Stock Option      
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]      
Securities excluded 906,892 192,273  
Convertible debt      
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]      
Securities excluded 2,114,403 162,602