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Consolidated Statements of Cash Flows (Unaudited) - USD ($)
3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Operating activities:    
Net loss $ (4,349,021) $ (2,362,478)
Adjustments to reconcile net loss to net cash used in operating activities:    
Amortization and depreciation 8,232 8,899
Non-cash lease expense 30,925 27,995
Share-based compensation 78,271 94,805
Issuance of common stock to vendors 50,001  
Amortization of deferred issuance costs associated with convertible debt 10,242 10,155
Change in operating assets and liabilities:    
Contracts and grants receivable 15,197 42,050
Prepaid expenses and other current assets (70,732) (245,384)
Research and development incentives receivable 55,466 327,293
Operating lease liability (30,921) (27,996)
Accounts payable and accrued expenses 1,228,383 (1,032,095)
Accrued compensation (264,886) (828,471)
Net cash used in operating activities (3,238,843) (3,985,227)
Investing activities:    
Purchases of office furniture and equipment (9,823)  
Net cash used in investing activities (9,823)  
Financing activities:    
Proceeds from issuance of common stock pursuant to B. Riley At Market Issuance Sales Agreement   16,395,606
Costs associated with B. Riley At Market Issuance Sales Agreement   (492,445)
Proceeds from the exercise of warrants   51
Costs associated with issuance of convertible debt   (45,512)
Principal repayment - financing lease   (1,999)
Net cash provided by financing activities   15,855,701
Effect of exchange rate on cash and cash equivalents 80,448 (5,193)
Net (decrease)/increase in cash and cash equivalents (3,168,218) 11,865,281
Cash and cash equivalents at beginning of period 26,043,897 18,676,663
Cash and cash equivalents at end of period 22,875,679 30,541,944
Supplemental information:    
Cash paid for state income taxes   2,132
Cash paid for interest 223,901 221,178
Cash paid for lease liabilities:    
Operating lease $ 33,325 33,325
Financing lease   2,136
Non-cash activities:    
Deferred issuance cost reclassified to additional-paid-in capital   $ 47,452