Summary of Significant Accounting Policies - Loss per share (Details) - shares	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Securities excluded	4,694,036	10,164,292
Warrants
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Securities excluded	59,872	5,731,464
Stock options
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Securities excluded	2,195,140	1,993,804
Convertible debt securities
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Securities excluded	2,439,024	2,439,024