Consolidated Statements of Changes in Shareholders Equity - USD ($)	Common Stock	Additional Paid-In Capital	Accumulated Other Comprehensive Loss	Accumulated Deficit	Total
Balance at Dec. 31, 2019	$ 21,753	$ 177,006,004	$ (45,010)	$ (175,525,612)	$ 1,457,135
Balance (in shares) at Dec. 31, 2019	21,753,124
Issuance of common stock pursuant to B. Riley At Market Issuance Sales Agreement	$ 6,439	14,191,721			14,198,160
Issuance of common stock pursuant to B. Riley At Market Issuance Sales Agreement (in shares)	6,438,431
Cost associated with issuance of common stock		(580,456)			(580,456)
Issuance of common stock for milestones	$ 1,956	4,998,044			5,000,000
Issuance of common stock for milestones (in shares)	1,956,182
Issuance of common stock to vendors	$ 30	58,970			59,000
Issuance of common stock to vendors (in shares)	30,000
Exercise of warrants	$ 460	860,458			860,918
Exercise of warrants (in shares)	460,161
Exercise of common stock options	$ 6	4,981			$ 4,987
Exercise of common stock options (in shares)	5,758				5,758
Share-based compensation expense		409,933			$ 409,933
Foreign currency translation adjustment			20,673		20,673
Net loss				(17,688,522)	(17,688,522)
Balance at Dec. 31, 2020	$ 30,644	196,949,655	(24,337)	(193,214,134)	3,741,828
Balance (in shares) at Dec. 31, 2020	30,643,656
Issuance of common stock pursuant to B. Riley At Market Issuance Sales Agreement	$ 12,174	19,693,473			19,705,647
Issuance of common stock pursuant to B. Riley At Market Issuance Sales Agreement (in shares)	12,174,515
Cost associated with issuance of common stock		(655,156)			(655,156)
Issuance of common stock to vendors	$ 25	27,475			27,500
Issuance of common stock to vendors (in shares)	25,000
Exercise of warrants		79			79
Exercise of warrants (in shares)	20
Exercise of common stock options	$ 30	25,805			$ 25,835
Exercise of common stock options (in shares)	30,254				30,254
Share-based compensation expense		361,559			$ 361,559
Foreign currency translation adjustment			66,279		66,279
Net loss				(12,550,973)	(12,550,973)
Balance at Dec. 31, 2021	$ 42,873	$ 216,402,890	$ 41,942	$ (205,765,107)	$ 10,722,598
Balance (in shares) at Dec. 31, 2021	42,873,445