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Summary of Significant Accounting Policies - Loss per share (Details) - shares
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Securities excluded 5,443,897 7,665,281
Warrants    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Securities excluded 3,328,072 5,731,477
Stock options    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Securities excluded 2,115,825 1,933,804