Document And Entity Information - USD ($)	12 Months Ended
	Dec. 31, 2021	Mar. 22, 2022	Jun. 30, 2021
[DocumentAndEntityInformationAbstract]
Entity Registrant Name	SOLIGENIX, INC.
Document Type	10-K
Current Fiscal Year End Date	--12-31
Document Annual Report	true
Document Transition Report	false
Entity Common Stock, Shares Outstanding		42,954,091
Entity Public Float			$ 39,976,044
Amendment Flag	false
Entity Central Index Key	0000812796
Entity Current Reporting Status	Yes
Entity Voluntary Filers	No
Entity Filer Category	Non-accelerated Filer
Entity Well-known Seasoned Issuer	No
Document Period End Date	Dec. 31, 2021
Document Fiscal Year Focus	2021
Document Fiscal Period Focus	FY
Entity Small Business	true
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity File Number	000-16929
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	41-1505029
Entity Address, Address Line One	29 EMMONS DRIVE
Entity Address, Address Line Two	SUITE B-10
Entity Address, City or Town	PRINCETON
Entity Address, State or Province	NJ
Entity Address, Postal Zip Code	08540
City Area Code	609
Local Phone Number	538-8200
Title of 12(b) Security	Common Stock, par value $0.01 per share
Trading Symbol	SNGX
Security Exchange Name	NASDAQ
ICFR Auditor Attestation Flag	false
Entity Interactive Data Current	Yes
Auditor Name	EISNERAMPER LLP
Auditor Firm ID	274
Auditor Location	Iselin, New Jersey