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Consolidated Statements of Cash Flows (Unaudited) - USD ($)
9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Operating activities:    
Net loss $ (7,847,097) $ (12,148,257)
Adjustments to reconcile net loss to cash used in operating activities:    
Amortization and depreciation 26,614 52,635
Non-cash lease expense 86,124 100,720
Share-based compensation 255,147 211,266
Issuance of common stock for milestone   5,000,000
Issuance of common stock to vendor 27,500 59,000
Amortization of deferred issuance costs associated with convertible debt 31,456  
Gain on forgiveness of PPP loan (421,584)  
Change in operating assets and liabilities:    
Contracts and grants receivable 159,590 624,433
Prepaid expenses and other current assets (203,619) (70,500)
Research and development incentives receivable 258,509 (5,164)
Operating lease liability (86,124) (101,779)
Accounts payable and accrued expenses (154,415) (827,680)
Accrued compensation (816,367) (224,145)
Net cash used in operating activities (8,684,266) (7,329,471)
Investing activities:    
Purchases of office furniture and equipment   (7,147)
Net cash used in investing activities   (7,147)
Financing activities:    
Proceeds from issuance of common stock pursuant to B. Riley At Market Issuance Sales Agreement 19,417,290 12,691,268
Costs associated with B. Riley At Market Issuance Sales Agreement (584,334) (551,755)
Proceeds from the exercise of warrants 51 685,384
Proceeds from the exercises of stock options 25,835 4,987
Costs associated with issuance of convertible debt (45,512)  
Proceeds from paycheck protection program   417,830
Principal repayment - financing lease (6,149) (5,566)
Net cash provided by financing activities 18,807,181 13,242,148
Effect of exchange rate on cash and cash equivalents 67,909 16,556
Net increase in cash and cash equivalents 10,190,824 5,922,086
Cash and cash equivalents at beginning of period 18,676,663 5,420,708
Cash and cash equivalents at end of period 28,867,487 11,342,794
Supplemental information:    
Cash paid for state income taxes 7,382 4,021
Cash paid for interest 444,814  
Cash paid for lease liabilities:    
Operating lease 99,975 106,950
Financing lease 6,408 6,408
Non-cash activities:    
Right-of-use assets and lease liabilities recorded   240,727
Deferred issuance cost in accounts payable 22,700 57,884
Deferred issuance cost reclassified to additional-paid-in capital $ 55,572 $ 124,981