Consolidated Statements of Changes in Shareholders' Equity (Unaudited) - USD ($)	Common Stock	Additional Paid-In Capital	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit	Total
Balance at Dec. 31, 2019	$ 21,753	$ 177,006,004	$ (45,010)	$ (175,525,612)	$ 1,457,135
Balance (in shares) at Dec. 31, 2019	21,753,124
Issuance of common stock pursuant to B. Riley At Market Issuance Sales Agreement	$ 5,797	12,685,471			12,691,268
Issuance of common stock pursuant to B. Riley At Market Issuance Sales Agreement (in shares)	5,797,403
Issuance costs associated with B. Riley At Market Issuance Sales Agreement		(591,079)			(591,079)
Issuance of common stock for milestone	$ 1,956	4,998,044			5,000,000
Issuance of common stock for milestone (in shares)	1,956,182
Issuance of common stock to vendors	$ 30	58,970			59,000
Issuance of common stock to vendors (in shares)	30,000
Exercise of common stock options	$ 6	4,981			4,987
Options exercised (in shares)	5,758
Exercise of warrants	$ 305	685,079			685,384
Exercise of warrants (in shares)	304,821
Share-based compensation expense		211,266			211,266
Foreign currency translation adjustment			35,767		35,767
Net loss				(12,148,257)	(12,148,257)
Balance at Sep. 30, 2020	$ 29,847	195,058,736	(9,243)	(187,673,869)	7,405,471
Balance (in Shares) at Sep. 30, 2020	29,847,288
Balance at Jun. 30, 2020	$ 28,591	191,922,671	(36,951)	(185,883,709)	6,030,602
Balance (in shares) at Jun. 30, 2020	28,591,432
Issuance of common stock pursuant to B. Riley At Market Issuance Sales Agreement	$ 1,252	3,230,067			3,231,319
Issuance of common stock pursuant to B. Riley At Market Issuance Sales Agreement (in shares)	1,252,287
Issuance costs associated with B. Riley At Market Issuance Sales Agreement		(165,555)			(165,555)
Exercise of common stock options	$ 4	4,981			4,985
Options exercised (in shares)	3,569
Share-based compensation expense		66,572			66,572
Foreign currency translation adjustment			27,708		27,708
Net loss				(1,790,160)	(1,790,160)
Balance at Sep. 30, 2020	$ 29,847	195,058,736	(9,243)	(187,673,869)	7,405,471
Balance (in Shares) at Sep. 30, 2020	29,847,288
Balance at Dec. 31, 2020	$ 30,644	196,949,655	(24,337)	(193,214,134)	3,741,828
Balance (in shares) at Dec. 31, 2020	30,643,656
Issuance of common stock pursuant to B. Riley At Market Issuance Sales Agreement	$ 11,931	19,405,359			19,417,290
Issuance of common stock pursuant to B. Riley At Market Issuance Sales Agreement (in shares)	11,931,513
Issuance costs associated with B. Riley At Market Issuance Sales Agreement		(639,906)			(639,906)
Issuance of common stock to vendors	$ 25	27,475			27,500
Issuance of common stock to vendors (in shares)	25,000
Exercise of common stock options	$ 30	25,805			$ 25,835
Options exercised (in shares)	30,254				30,254
Exercise of warrants		51			$ 51
Exercise of warrants (in shares)	13
Share-based compensation expense		255,147			255,147
Foreign currency translation adjustment			73,895		73,895
Net loss				(7,847,097)	(7,847,097)
Balance at Sep. 30, 2021	$ 42,630	216,023,586	49,558	(201,061,231)	15,054,543
Balance (in Shares) at Sep. 30, 2021	42,630,436
Balance at Jun. 30, 2021	$ 40,079	213,061,849	(32,058)	(197,473,680)	15,596,190
Balance (in shares) at Jun. 30, 2021	40,078,760
Issuance of common stock pursuant to B. Riley At Market Issuance Sales Agreement	$ 2,496	2,924,465			2,926,961
Issuance of common stock pursuant to B. Riley At Market Issuance Sales Agreement (in shares)	2,496,422
Issuance costs associated with B. Riley At Market Issuance Sales Agreement		(95,729)			(95,729)
Issuance of common stock to vendors	$ 25	27,475			27,500
Issuance of common stock to vendors (in shares)	25,000
Exercise of common stock options	$ 30	25,805			25,835
Options exercised (in shares)	30,254
Share-based compensation expense		79,721			79,721
Foreign currency translation adjustment			81,616		81,616
Net loss				(3,587,551)	(3,587,551)
Balance at Sep. 30, 2021	$ 42,630	$ 216,023,586	$ 49,558	$ (201,061,231)	$ 15,054,543
Balance (in Shares) at Sep. 30, 2021	42,630,436