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Consolidated Statements of Cash Flows - USD ($)
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Operating activities:    
Net loss $ (17,688,522) $ (9,355,592)
Adjustments to reconcile net loss to net cash used in operating activities:    
Amortization and depreciation 62,372 54,450
Noncash lease expense 130,670 123,110
Share-based compensation 409,933 376,339
Issuance of common stock for milestone 5,000,000
Issuance of common stock for services 59,000 159,238
Deferred issuance costs written off 61,609  
Amortization of deferred issuance costs associated with convertible debt 1,205  
Gain on disposition of office furniture (3,843)
Change in operating assets and liabilities:    
Contracts and grants receivable 815,061 182,880
Prepaid expenses and other current assets 384,424 (452,255)
Security deposit (20) (23)
Research and development incentives receivable 21,924 (444,043)
Operating lease liability (131,845) (121,938)
Accounts payable and accrued expenses (1,157,160) 1,968,565
Accrued compensation 576,923 3,545
Net cash used in operating activities (11,454,426) (7,509,567)
Investing activities:    
Purchases of office furniture and equipment (7,147) (30,209)
Proceeds from sale of office furniture 5,500
Net cash used in investing activities (7,147) (24,709)
Financing activities:    
Proceeds from issuance of common stock pursuant to FBR At Market Issuance Sales Agreement 14,198,160 4,142,456
Costs associated with issuance of common stock (656,264) (132,080)
Proceeds from exercise of warrants 860,918
Proceeds from the exercises of stock options 4,987 1,882
Proceeds from paycheck protection program 417,830
Proceeds from convertible debt 10,000,000
Costs associated with issuance of convertible debt (141,466)  
Principal repayment – financing lease (7,516) (6,803)
Net cash provided by financing activities 24,676,649 4,005,455
Effect of exchange rate on cash and cash equivalents 40,879 (34,188)
Net increase (decrease) in cash and cash equivalents 13,255,955 (3,563,009)
Cash and cash equivalents at beginning of year 5,420,708 8,983,717
Cash and cash equivalents at end of year 18,676,663 5,420,708
Supplemental information:    
Cash paid for state income taxes 4,021 11,132
Cash paid for interest 34,406  
Cash paid for lease liabilities:    
Operating lease: 141,050 140,017
Financing lease: 8,544 8,544
Right-of use assets and lease liabilities recorded 240,727 255,965
Deferred issuance cost reclassified to additional-paid-in capital 67,733 33,535
Issuance of restricted common stock to vendor for website development costs 46,500
Issuance of common stock to vendor included in prepaid expenses $ 2,550