Consolidated Statements of Changes in Shareholders’ Equity - USD ($)	Common Stock	Additional Paid-In Capital	Accumulated Other Comprehensive Loss	Accumulated Deficit	Total
Balance at Dec. 31, 2018	$ 17,683	$ 172,436,176	$ (3,669)	$ (166,170,020)	$ 6,280,170
Balance (in Shares) at Dec. 31, 2018	17,682,839
Issuance of common stock pursuant to FBR At Market Issuance Sales Agreement	$ 3,824	4,138,632			4,142,456
Issuance of common stock pursuant to FBR At Market Issuance Sales Agreement (in Shares)	3,824,585
Cost associated with issuance of common stock		(152,517)			(152,517)
Issuance of common stock to vendors	$ 246	205,492			205,738
Issuance of common stock to vendors (in Shares)	245,700
Exercise of common stock options		1,882			$ 1,882
Exercise of common stock options (in Shares)					2,189
Share-based compensation expense		376,339			$ 376,339
Foreign currency translation adjustment			(41,341)		(41,341)
Net loss				(9,355,592)	(9,355,592)
Balance at Dec. 31, 2019	$ 21,753	177,006,004	(45,010)	(175,525,612)	1,457,135
Balance (in Shares) at Dec. 31, 2019	21,753,124
Issuance of common stock pursuant to FBR At Market Issuance Sales Agreement	$ 6,439	14,191,721			14,198,160
Issuance of common stock pursuant to FBR At Market Issuance Sales Agreement (in Shares)	6,438,431
Cost associated with issuance of common stock		(580,456)			(580,456)
Issuance of common stock for milestone	$ 1,956	4,998,044			5,000,000
Issuance of common stock for milestone (in Shares)	1,956,182
Issuance of common stock to vendors	$ 30	58,970			59,000
Issuance of common stock to vendors (in Shares)	30,000
Exercise of warrants	$ 460	860,458			860,918
Exercise of warrants (in Shares)	460,161
Exercise of common stock options	$ 6	4,981			4,987
Exercise of common stock options (in Shares)	5,758
Share-based compensation expense		409,933			409,933
Foreign currency translation adjustment			20,673		20,673
Net loss				(17,688,522)	(17,688,522)
Balance at Dec. 31, 2020	$ 30,644	$ 196,949,655	$ (24,337)	$ (193,214,134)	$ 3,741,828
Balance (in Shares) at Dec. 31, 2020	30,643,656