Consolidated Statements of Changes in Shareholders' Equity (Unaudited) - USD ($)	Common Stock	Additional Paid-In Capital	Accumulated Other Comprehensive Loss	Accumulated Deficit	Total
Balance at Dec. 31, 2018	$ 17,683	$ 172,436,176	$ (3,669)	$ (166,170,020)	$ 6,280,170
Balance, Shares at Dec. 31, 2018	17,682,839
Issuance of common stock pursuant to FBR At Market Issuance Sales Agreement	$ 446	$ 522,137			$ 522,583
Issuance of common stock pursuant to FBR At Market Issuance Sales Agreement, shares	446,369
Issuance costs associated with FBR At Market Issuance Sales Agreement, shares		(19,382)			(19,382)
Issuance of restricted common stock to vendors	$ 60	$ 57,540			$ 57,600
Issuance of restricted common stock to vendors, shares	60,000
Share-based compensation expense		79,573			79,573
Foreign currency translation adjustment			649		649
Net loss				(1,639,627)	(1,639,627)
Balance at Mar. 31, 2019	$ 18,189	173,076,044	(3,020)	(167,809,647)	5,281,566
Balance, Shares at Mar. 31, 2019	18,189,208
Balance at Dec. 31, 2019	$ 21,753	177,006,004	(45,010)	(175,525,612)	1,457,135
Balance, Shares at Dec. 31, 2019	21,753,124
Issuance of common stock in public financing, net of underwriting discount					78,338
Issuance of common stock pursuant to FBR At Market Issuance Sales Agreement	$ 1,732	3,987,494			3,989,226
Issuance of common stock pursuant to FBR At Market Issuance Sales Agreement, shares	1,732,115
Issuance costs associated with FBR At Market Issuance Sales Agreement		(174,721)			(174,721)
Issuance of common stock for milestone	$ 1,956	4,998,044			5,000,000
Issuance of common stock for milestone, shares	1,956,182
Issuance of restricted common stock to vendors	$ 30	58,970			59,000
Issuance of restricted common stock to vendors, shares	30,000
Exercise of common stock options	$ 2				2
Exercise of common stock options, Shares	2,189
Exercise of warrants	$ 305	685,079			685,384
Exercise of warrants, shares	304,821
Share-based compensation expense		63,691			63,691
Foreign currency translation adjustment			16,243		16,243
Net loss				(7,581,334)	(7,581,334)
Balance at Mar. 31, 2020	$ 25,778	$ 186,624,561	$ (28,767)	$ (183,106,946)	$ 3,514,626
Balance, Shares at Mar. 31, 2020	25,778,431