Consolidated Statements of Changes in Shareholders' Equity - USD ($)	Common Stock	Additional Paid-In Capital	Accumulated Other Comprehensive Loss	Accumulated Deficit	Total
Balance at Dec. 31, 2017	$ 8,731	$ 163,581,026		$ (157,270,045)	$ 6,319,712
Balance, Shares at Dec. 31, 2017	8,730,640
Issuance of common stock pursuant to Lincoln Park Equity Line	$ 20	38,380			38,400
Issuance of common stock pursuant to Lincoln Park Equity Line, shares	20,161
Issuance of common stock in public offering	$ 8,932	8,628,014			8,636,946
Issuance of common stock in public offering, shares	8,932,038
Costs associated with public offering		(192,130)			(192,130)
Share-based compensation expense		380,886			380,886
Foreign currency translation adjustment			(3,669)		(3,669)
Net loss				(8,899,975)	(8,899,975)
Balance at Dec. 31, 2018	$ 17,683	172,436,176	(3,669)	(166,170,020)	6,280,170
Balance, Shares at Dec. 31, 2018	17,682,839
Issuance of common stock pursuant to FBR At-the-Market Sales Agreement	$ 3,824	4,138,632			4,142,456
Issuance of common stock pursuant to FBR At-the-Market Sales Agreement, shares	3,824,585
Cost associated with issuance of common stock		(152,517)			(152,517)
Issuance of restricted common stock to vendors	$ 246	205,492			205,738
Issuance of restricted common stock to vendors, shares	245,700
Exercise of common stock options		1,882			1,882
Exercise of common stock options, Shares
Share-based compensation expense		376,339			376,339
Foreign currency translation adjustment			(41,341)		(41,341)
Net loss				(9,355,592)	(9,355,592)
Balance at Dec. 31, 2019	$ 21,753	$ 177,006,004	$ (45,010)	$ (175,525,612)	$ 1,457,135
Balance, Shares at Dec. 31, 2019	21,753,124