Stock Option Plans and Warrants to Purchase Common Stock (Details 4) - $ / shares	12 Months Ended
Dec. 31, 2019	Dec. 31, 2018
Warrants
Granted	596,740
Weighted Average Exercise Price
Exercised	$ 3.77
Warrant [Member]
Warrants
Beginning balance	6,303,643	2,577,238
Granted		3,738,155
Exercised
Expired	(110,932)	(11,750)
Ending balance	6,192,711	6,303,643
Weighted Average Exercise Price
Beginning balance	$ 3.09	$ 4.38
Granted		2.20
Exercised
Expired	14.80	1.64
Ending balance	$ 2.88	$ 3.09

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Number of options or other stock instruments for which the right to exercise has lapsed under the terms of the plan agreements.

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Gross number of share options (or share units) granted during the period.

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Number of options outstanding, including both vested and non-vested options.

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Weighted average price at which option holders acquired shares when converting their stock options into shares.

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Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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