Stock Option Plans and Warrants to Purchase Common Stock (Details 2)	12 Months Ended
	Dec. 31, 2019 $ / shares shares
Options [Member]
Weighted Average Remaining Contractual Life in Years	8 years 2 months 1 day
Outstanding Options	1,506,972
Exercisable Options	908,178
$0.71-$17.20 [Member]
Price Range, lower range limit | $ / shares	$ 0.71
Price Range, upper range limit | $ / shares	$ 17.20
Weighted Average Remaining Contractual Life in Years	8 years 5 months 16 days
Outstanding Options	1,431,154
Exercisable Options	832,360
$20.00-$39.80 [Member]
Price Range, lower range limit | $ / shares	$ 20.00
Price Range, upper range limit | $ / shares	$ 39.80
Weighted Average Remaining Contractual Life in Years	3 years 9 months 3 days
Outstanding Options	50,830
Exercisable Options	50,830
$41.00-$48.00 [Member]
Price Range, lower range limit | $ / shares	$ 41.00
Price Range, upper range limit | $ / shares	$ 48.00
Weighted Average Remaining Contractual Life in Years	7 months 28 days
Outstanding Options	24,988
Exercisable Options	24,988