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Income Taxes (Details 2)
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Income Taxes [Abstract]    
Federal tax at statutory rate (34.00%) (34.00%)
State tax benefits, plus sale of NJ NOL, net of federal benefit (11.60%) (7.90%)
Permanent differences 5.70% 10.30%
Orphan drug and research and development credits (13.90%) (38.80%)
Change in statutory rate 186.90%  
Change in valuation allowance (138.60%) 56.40%
Income tax benefit (5.50%) (14.00%)