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Warrant Liability (Details) - $ / shares
1 Months Ended 9 Months Ended 12 Months Ended
Jun. 25, 2013
Sep. 30, 2016
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Warrant [Member]          
Summary of assumptions used in connection with the valuation of warrants issued          
Number of shares underlying the warrants 541,685 303,694 303,693 472,336 530,944
Exercise price $ 16.50 $ 5.10 $ 5.10 $ 6.10 $ 16.50
Volatility 140.00% 90.00% 98.00% 128.00% 135.00%
Risk-free interest rate 1.49% 0.68% 1.19% 1.38% 1.75%
Expected dividend yield 0.00% 0.00% 0.00% 0.00% 0.00%
Expected warrant life (years) 5 years 1 year 8 months 23 days 2 years 5 months 23 days 3 years 6 months 4 years 6 months
Stock price $ 9.60 $ 7.70 $ 11.30 $ 9.80 $ 18.00
Exercised During 2015 [Member]          
Summary of assumptions used in connection with the valuation of warrants issued          
Number of shares underlying the warrants     168,643    
Exercise price     $ 6.10    
Volatility     98.00%    
Risk-free interest rate     1.19%    
Expected dividend yield     0.00%    
Expected warrant life (years)     2 years 5 months 23 days    
Exercised During 2015 [Member] | Maximum [Member]          
Summary of assumptions used in connection with the valuation of warrants issued          
Volatility     119.00%    
Risk-free interest rate     1.06%    
Expected warrant life (years)     3 years 3 months 29 days    
Stock price     $ 2.22    
Exercised During 2015 [Member] | Minimum [Member]          
Summary of assumptions used in connection with the valuation of warrants issued          
Volatility     117.00%    
Risk-free interest rate     0.81%    
Expected warrant life (years)     3 years 4 days    
Stock price     $ 1.69