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Consolidated Statements of Cash Flows - USD ($)
3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Operating activities:    
Net loss $ (1,149,433) $ (4,569,322)
Adjustments to reconcile net loss to net cash used in operating activities:    
Amortization and depreciation $ 22,607 59,926
Common stock issued to vendors 101,360
Share-based compensation $ 136,411 $ 142,025
Amortization of discount on debt 6,251
Change in fair value of warrant liability (760,157) $ 3,011,616
Change in operating assets and liabilities:    
Contracts and grants receivable 961,911 449,347
Prepaid expenses 154,742 41,382
Accounts payable 252,835 (459,603)
Accrued compensation (263,006) (282,841)
Total adjustments 511,594 3,063,212
Net cash used in operating activities (637,839) (1,506,110)
Investing activities    
Purchases of office furniture and equipment (4,263) (11,553)
Net cash used in investing activities $ (4,263) (11,553)
Financing Activities:    
Net proceeds from issuance of common stock pursuant to the equity lines $ 246,525
Stock issuance cost associated with equity line purchase agreement $ (19,003)
Proceeds from exercises of options and warrants $ 758,649
Net cash (used in) provided by financing activities $ (19,003) 1,005,174
Net decrease in cash and cash equivalents (661,105) (512,489)
Cash and cash equivalents at beginning of period 4,921,545 5,525,094
Cash and cash equivalents at end of period $ 4,260,440 5,012,605
Supplemental disclosure of non cash investing and financing activities:    
Reclassification of warrant liability to additional paid in capital upon partial exercises of warrants issued in unit offering $ 1,648,811