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Stock Option Plans and Warrants to Purchase Common Stock (Details 4) - $ / shares
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Summary of options/warrants activity    
Ending Balance, weighted average options/warrants exercise price $ 1.19  
Warrant [Member]    
Summary of options/warrants activity    
Beginning Balance 7,269,500 8,156,526
Granted   1,169,318
Exercised (1,746,429) (586,081)
Expired/Cancelled (596,952) (1,470,263)
Ending Balance 4,926,119 7,269,500
Beginning Balance, weighted average options/warrants exercise price $ 1.15 $ 2.17
Granted, weighted average options/warrants exercise price   1.48
Exercised, weighted average options/warrants exercise price 0.64 1.65
Expired, weighted average warrant exercise price 5.59 3.49
Ending Balance, weighted average options/warrants exercise price $ 0.74 $ 1.15