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Stock Option Plans and Warrants to Purchase Common Stock (Details 1) - $ / shares
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]    
Ending Balance, weighted average options/warrants exercise price $ 1.19  
Stock options [Member]    
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]    
Beginning Balance 2,488,279 2,051,511
Granted 605,340 637,495
Exercised (33,125) (36,672)
Forfeited (291,882) (164,055)
Ending Balance 2,768,612 2,488,279
Beginning Balance, weighted average options/warrants exercise price $ 2.40 $ 2.63
Granted, weighted average options/warrants exercise price 1.19 1.79
Exercised, weighted average options/warrants exercise price 0.58 0.77
Forfeited, weighted average options exercise price 3.13 3.13
Ending Balance, weighted average options/warrants exercise price $ 2.13 $ 2.40