Consolidated Statements of Changes in Shareholders' Equity (Unaudited) (USD $)	Total	Common Stock	Additional Paid-In Capital	Accumulated Deficit
Beginning Balance at Dec. 31, 2012	$ 3,551,106	$ 11,169	$ 125,820,318	$ (122,280,381)
Beginning Balance, Shares at Dec. 31, 2012		11,168,905
Common stock issued in Unit offering	6,216,762	6,774	6,209,988
Common stock issued in Unit offering, Shares		6,773,995
Warrants issued in Unit offering	(4,827,788)		(4,827,788)
Issuance of common stock to collaboration partner	1,500,000	1,034	1,498,966
Issuance of common stock to collaboration partner, Shares		1,034,483
Issuance of common stock to vendors	59,588	43	59,545
Issuance of common stock to vendors, Shares		43,104
Exercise of shares from options	385,597	132	385,465
Exercise of shares from options and warrants ,shares		132,143
Stock-based compensation expense	571,171		571,171
Net loss	(11,052,427)			(11,052,427)
Balance at Sep. 30, 2013	$ (3,595,991)	$ 19,152	$ 129,717,665	$ (133,332,808)
Balance, Shares at Sep. 30, 2013		19,152,630