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Consolidated Statements of Cash Flows (USD $)
3 Months Ended 12 Months Ended
Mar. 31, 2013
Mar. 31, 2012
Dec. 31, 2012
Dec. 31, 2011
Operating activities:        
Net loss $ (1,087,414) $ (1,438,755) $ (4,163,008) $ (2,378,594)
Adjustments to reconcile net loss to net cash used in operating activities:        
Amortization and depreciation 56,498 57,344 230,630 226,027
Restricted stock issued to employee    10,000    
Restricted stock issued to vendors 32,888       
Common stock issued for amended license agreement        400,000
Issuance of common stock to employee     10,000 20,500
Common stock issued in exchange for services     21,000 26,184
Warrants replaced in exchange for renegotiated agreement     429,902   
Stock-based compensation 79,492 117,614 462,170 715,805
Capitalized patent write-off        88,727
Change in operating assets and liabilities:        
Grants receivable (317,544) 38,068 23,165 (241,686)
Taxes receivable    574,157 574,157 (322,293)
Prepaid expenses (30,085) 51,726 55,069 (8,268)
Accounts payable 527,238 (72,999) (179,053) (370,620)
Accrued compensation (5,432) (12,690) (99,565) (107,520)
Total adjustments 343,055 763,220 1,527,475 426,856
Net cash used in operating activities (744,359) (675,535) (2,635,533) (1,951,738)
Investing activities:        
Acquisition of intangible assets        (151,086)
Purchase of office equipment     (4,755) (1,578)
Net cash used in investing activities     (4,755) (152,664)
Financing activities:        
Net proceeds from sale of common stock          
Settlement of broker fees associated with 2010 financing        40,743
Proceeds from sale of common stock pursuant to equity line        355,000
Proceeds from exercise of options and warrants        253,613
Net cash provided by financing activities        649,356
Net decrease in cash and cash equivalents (744,359) (675,535) (2,640,288) (1,455,046)
Cash and cash equivalents at beginning of period 3,356,380 5,996,668 5,996,668 7,451,714
Cash and cash equivalents at end of period 2,612,021 5,321,133 3,356,380 5,996,668
Supplemental information:        
Cash paid for state income taxes     $ 2,730 $ 2,750