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Stock Option Plans and Warrants to Purchase Common Stock (Details 3) (Warrant [Member], USD $)
12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Warrant [Member]
   
Summary of options/warrants activity    
Beginning Balance 2,701,569 2,703,819
Granted 774,873 4,750
Number of stock issued from stock option exercises      
Expired (633,104) (7,000)
Ending Balance 2,843,338 2,701,569
Beginning Balance, weighted average options/warrants exercise price $ 4.40 $ 4.40
Granted, weighted average options/warrants exercise price $ 0.56 $ 3.85
Exercised, weighted average options/warrants exercise price      
Expired, weighted average warrant exercise price $ 5.40 $ 0.66
Ending Balance, weighted average options/warrants exercise price $ 3.13 $ 4.40