DORBioPharma, Inc.

December 12, 2005

Confidential

Kind Attn: Hans T. Schambye, PhD

Chief Executive Officer

Gastrotech Pharma A/S

Nyhavn 43B

Copenhagen 1051

Denmark

Re: Extension of Letter of Intent between DOR BioPharma, Inc., Gastrotech Pharma A/S and Sellers dated October 28, 2005 (“Letter of Intent”)

Dear Hans:

This letter confirms our mutual agreement as of the date set forth above to extend both the termination date set forth in sub-clause (i) on page 4 of the Letter of Intent and the exclusivity period set forth on page 4 of the Letter of Intent through 11:59 pm (Eastern Standard Time) on January 15, 2006. All other terms of the Letter of Intent shall remain unchanged.

Agreed and Accepted on December 29, 2005	Agreed and Accepted on December 20, 2005
DOR BIOPHARMA, INC.	GASTROTECH PHARMA A/S
By: /s/ Michael Sember	By: /s/ Hans T. Schambye
Mike Sember	Hans T. Schambye, PhD
Chief Executive Officer	Chief Executive Officer
	By: /s/ Olle Isaksson
	Olle Isaksson
	Chairman of the Board of Directors
	NORDIC BIOTECH K/S
	By: /s/ Christian Hansen/s/ Florian Schonharting
	Christian Hansen  Florian Schonharting