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Assumptions Used in Estimating Fair Value of Stock Options Granted (Detail) - $ / shares
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions And Methodology [Abstract]      
Expected term (years) 6 years 1 month 6 days 5 years 6 months 6 years
Volatility 111.00% 103.00% 85.00%
Annual dividend per share $ 0 $ 0 $ 0
Risk-free interest rate 1.00% 0.40% 2.60%