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                          May 12, 2023

       John R. Beaver
       President and Chief Executive Officer
       BIOLASE, INC
       27042 Towne Centre Drive, Suite 270
       Lake Forest, California 92610

                                                        Re: BIOLASE, INC
                                                            Registration
Statement on Form S-1
                                                            Filed May 4, 2023
                                                            File No. 333-271660

       Dear John R. Beaver:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Margaret
Schwartz at 202-551-7153 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Industrial Applications and

                          Services
       cc:                                              Patrick Egan, Esq.