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                           November 29, 2022

       John Beaver
       President & Chief Executive Officer
       BIOLASE, Inc.
       27042 Towne Centre Drive, Suite 270
       Lake Forest, CA 92610

                                                        Re: BIOLASE, Inc.
                                                            Registration
Statement on Form S-1
                                                            Filed November 22,
2022
                                                            File No. 333-268528

       Dear John Beaver:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Jessica
Ansart at 202-551-4511 with any questions.




                           Sincerely,


                           Division of Corporation Finance

                           Office of Industrial Applications and

                           Services
       cc:                                              Istvan Hajdu