Note 11 - Stockholders' Equity - Non-vested Stock Options Activity (Details)	12 Months Ended
	Dec. 31, 2022 $ / shares shares
Outstanding, options (in shares)	7,885
Forfeited/cancelled, options (in shares)	(1,353)
Forfeited/cancelled, weighted average exercise price, options (in dollars per share) | $ / shares	$ 443.23
Outstanding, options (in shares)	6,403
Non-vested Stock Options [Member]
Outstanding, options (in shares)	1,643
Outstanding, nonvested, weighted average grant date fair value (in dollars per share) | $ / shares	$ 266.84
Vested (in shares)	(983)
Vested, nonvested, weighted average grant date fair value (in dollars per share) | $ / shares	$ 280.95
Forfeited/cancelled, options (in shares)	(305)
Forfeited/cancelled, weighted average exercise price, options (in dollars per share) | $ / shares	$ 278.55
Outstanding, options (in shares)	355
Outstanding, nonvested, weighted average grant date fair value (in dollars per share) | $ / shares	$ 217.71