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Note 10 - Subsequent Events (Details Textual) - USD ($)
1 Months Ended 3 Months Ended
Apr. 18, 2019
Apr. 30, 2019
Mar. 31, 2019
Class of Warrant or Right, Exercised During Period     500,000
Subsequent Event [Member] | April 2019 Pre-funded Warrants [Member]      
Class of Warrant or Right, Issued During Period 4,444,444    
Warrants Issued, Price Per Warrant $ 0.17    
Proceeds from Issuance of Warrants $ 755,555    
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right 1    
Class of Warrant or Right, Exercise Price of Warrants or Rights $ 0.01    
Subsequent Event [Member] | August 2018 Pre-funded Warrants [Member]      
Proceeds from Issuance of Warrants   $ 15,000  
Class of Warrant or Right, Exercise Price of Warrants or Rights   $ 0.01  
Class of Warrant or Right, Exercised During Period   1,500,000