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Note 8 - Segment Reporting (Tables)
6 Months Ended
Jun. 30, 2018
Notes Tables  
Reconciliation of Revenue from Segments to Consolidated [Table Text Block]
   
Three Months Ended June 30, 2018
 
   
Clinical
Development
   
Device
   
Total
 
Net revenues
  $
46,000
    $
1,958,000
    $
2,004,000
 
Cost of revenues
   
49,000
     
1,592,000
     
1,641,000
 
Gross profit
   
(3,000
)    
366,000
     
363,000
 
                         
Operating expenses
   
28,408,000
     
2,460,000
     
30,868,000
 
Operating loss
  $
(28,411,000
)   $
(2,094,000
)   $
(30,505,000
)
                         
Depreciation and amortization
  $
69,000
    $
105,000
    $
174,000
 
Impairment Charges
  $
27,202,000
    $
--
    $
27,202,000
 
Stock-based compensation expense
  $
122,000
    $
41,000
    $
163,000
 
   
Three Months Ended June 30, 2017
 
   
Clinical
Development
   
Device
   
Total
 
Net revenues
  $
113,000
    $
3,388,000
    $
3,501,000
 
Cost of revenues
   
111,000
     
1,862,000
     
1,973,000
 
Gross profit
   
2,000
     
1,526,000
     
1,528,000
 
                         
Operating expenses
   
1,899,000
     
1,361,000
     
3,260,000
 
Operating loss
  $
(1,897,000
)   $
165,000
    $
(1,732,000
)
                         
Depreciation and amortization
  $
110,000
    $
62,000
    $
172,000
 
Stock-based compensation expense
  $
100,000
    $
81,000
    $
181,000
 
   
Six Months Ended June 30, 2018
 
   
Clinical
Development
   
Device
   
Total
 
Net revenues
  $
108,000
    $
3,763,000
    $
3,871,000
 
Cost of revenues
   
120,000
     
3,036,000
     
3,156,000
 
Gross profit
   
(12,000
)    
727,000
     
715,000
 
                         
Operating expenses
   
29,588,000
     
4,889,000
     
34,477,000
 
Operating loss
  $
(29,600,000
)   $
(4,162,000
)   $
(33,762,000
)
                         
Depreciation and amortization
  $
137,000
    $
196,000
    $
333,000
 
Impairment Charges
  $
27,202,000
    $
--
    $
27,202,000
 
Stock-based compensation expense
  $
220,000
    $
80,000
    $
300,000
 
Goodwill
  $
500,000
    $
781,000
    $
1,281,000
 
Total assets
  $
12,808,000
    $
10,435,000
    $
23,243,000
 
   
Six Months Ended June 30, 2017
 
   
Clinical
Development
   
Device
   
Total
 
Net revenues
  $
266,000
    $
6,487,000
    $
6,753,000
 
Cost of revenues
   
235,000
     
3,613,000
     
3,848,000
 
Gross profit
   
31,000
     
2,874,000
     
2,905,000
 
                         
Operating expenses
   
3,880,000
     
2,920,000
     
6,800,000
 
Operating loss
  $
(3,849,000
)   $
(46,000
)   $
(3,895,000
)
                         
Depreciation and amortization
  $
226,000
    $
131,000
    $
357,000
 
Stock-based compensation expense
  $
251,000
    $
177,000
    $
428,000