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Note 7 - Stockholders' Equity (Tables)
3 Months Ended
Mar. 31, 2018
Notes Tables  
Share-based Compensation, Stock Options, Activity [Table Text Block]
   
Number of
Shares
   
Weighted-
Average
Exercise
Price
   
Weighted-
Average
Remaining
Contractual
Life
   
Aggregate
Intrinsic
Value
 
                                 
Outstanding at December 31, 2017
   
1,156,027
    $
3.92
     
 
     
 
 
                                 
Granted
   
80,000
    $
3.00
     
 
     
 
 
Forfeited
   
(2,435
)   $
3.53
     
 
     
 
 
Expired
   
(27,182
)   $
4.67
     
 
     
 
 
                                 
Outstanding at March 31, 2018
   
1,206,410
    $
3.84
     
8.5
     
--
 
                                 
Vested and expected to vest at March 31, 2018
   
943,103
    $
4.07
     
8.3
     
--
 
                                 
Exercisable at March 31, 2018
   
306,582
    $
6.22
     
5.7
     
--
 
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Expected life (years)
   
5.6
 
Risk-free interest rate
   
2.7
%
Expected volatility
   
98
%
Dividend yield
   
0
%
Schedule of Share-based Compensation, Restricted Stock and Restricted Stock Units Activity [Table Text Block]
           
Weighted
Average
 
   
Number of
Shares
   
Grant Date
Fair Value
 
Balance at December 31, 2017
   
416
    $
17.60
 
Granted
   
--
     
 
 
Vested
   
--
     
 
 
Forfeited
   
--
     
 
 
Outstanding at March 31, 2018
   
416
    $
17.60
 
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
   
Number of
Shares
   
Weighted-Average
Exercise Price Per
Share
 
Balance at December 31, 2017
   
4,828,723
    $
9.37
 
Warrants granted
   
304,818
     
2.68
 
Warrants canceled
   
--
     
--
 
Warrants exercised
   
--
     
--
 
                 
Outstanding at March 31, 2018
   
5,133,541
    $
8.97
 
                 
Exercisable at March 31, 2018
   
4,130,194
    $
9.60