Exhibit 1

                       Schedule 13D Joint Filing Agreement

The undersigned and each other person executing this joint filing agreement
(this "Agreement") agree as follows:

The undersigned and each other person executing this Agreement are responsible
for the timely filing of such Schedule 13D and any amendments thereto, and for
the completeness and accuracy of the information concerning such person
contained therein; but none of the undersigned or any other person executing
this Agreement is responsible for the completeness or accuracy of the
information statement concerning any other persons making the filing, unless
such person knows or has reason to believe that such information is inaccurate.

After reasonable inquiry and to the best of my knowledge and belief, the
undersigned certifies that the information set forth in this statement is true,
complete, and correct

In Witness Whereof, the undersigned have caused this Agreement to be signed by
their respective officers thereunto duly authorized as of the date set forth
below.

Date: February 12, 2008

Signatures:


Life Sciences Opportunities Fund II, L.P.

By: LOF Partners, LLC, general partner

By  /s/ James C. Gale
    -------------------------------
Name: James C. Gale
Title: Manager


Life Sciences Opportunities Fund II (Institutional), L.P.

By: Signet Healthcare Partners, LLC, general partner

By  /s/ James C. Gale
    -------------------------------
Name: James C. Gale
Title: Manager


Signet Healthcare Partners, LLC

By  /s/ James C. Gale
    -------------------------------
Name: James C. Gale
Title: Manager


SOF Management, LLC

By  /s/ Don S. Sanders
    -------------------------------
Name: Don A. Sanders
Title: Manager




SMH Capital Inc.

By  /s/ John T. Unger
    -------------------------------
Name: John T. Unger
Title: Senior Vice President and General Counsel


/s/ Don A. Sanders
-----------------------------------
Don A. Sanders


/s/ James C. Gale
-----------------------------------
Name: James C. Gale