Exhibit 23.1

CONSENT OF BURR, PILGER & MAYER LLP,

 INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in this Registration Statement on Form S-3 of our report dated March 4, 2005 relating to the consolidated financial statements of InSite Vision Incorporated which appears in InSite Vision Incorporated’s Annual Report on Form 10-K for the year ended December 31, 2004. We also consent to the reference to us under the heading “Experts” in such Registration Statement.

/s/ Burr, Pilger & Mayer LLP

Palo Alto, California

December 9, 2005