<SEC-DOCUMENT>0000080255-21-001310-index.html : 20210216
<SEC-HEADER>0000080255-21-001310.hdr.sgml : 20210216
<ACCEPTANCE-DATETIME>20210216122400
ACCESSION NUMBER:		0000080255-21-001310
CONFORMED SUBMISSION TYPE:	SC 13G/A
CONFIRMING COPY:	
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20210216
DATE AS OF CHANGE:		20210216

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Orchard Therapeutics plc
		CENTRAL INDEX KEY:			0001748907
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			X0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-90710

	BUSINESS ADDRESS:	
		STREET 1:		108 CANNON STREET
		CITY:			LONDON
		STATE:			X0
		ZIP:			EC4N 6EU
		BUSINESS PHONE:		011-44-0-203-3846700

	MAIL ADDRESS:	
		STREET 1:		108 CANNON STREET
		CITY:			LONDON
		STATE:			X0
		ZIP:			EC4N 6EU

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Orchard Rx Ltd
		DATE OF NAME CHANGE:	20180802

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PRICE T ROWE ASSOCIATES INC /MD/
		CENTRAL INDEX KEY:			0000080255
		STANDARD INDUSTRIAL CLASSIFICATION:	SECURITY & COMMODITY BROKERS, DEALERS, EXCHANGES & SERVICES [6200]
		IRS NUMBER:				520556948
		STATE OF INCORPORATION:			MD
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		100 EAST PRATT ST
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21202
		BUSINESS PHONE:		(410)345-2000

	MAIL ADDRESS:	
		STREET 1:		P.O. BOX 89000
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21289
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>ortx13gadec20.txt
<TEXT>
Document 1 - file: ortx13gadec20.txt

</DOCUMENT>
</SEC-DOCUMENT>