<SEC-DOCUMENT>0000080255-19-002683-index.html : 20190214
<SEC-HEADER>0000080255-19-002683.hdr.sgml : 20190214
<ACCEPTANCE-DATETIME>20190214135103
ACCESSION NUMBER:		0000080255-19-002683
CONFORMED SUBMISSION TYPE:	SC 13G/A
CONFIRMING COPY:	
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20190214
DATE AS OF CHANGE:		20190214

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Spark Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001609351
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				462654405
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-88577

	BUSINESS ADDRESS:	
		STREET 1:		3737 MARKET STREET
		STREET 2:		SUITE 1300
		CITY:			PHILADELPHIA
		STATE:			PA
		ZIP:			19104
		BUSINESS PHONE:		888-772-7560

	MAIL ADDRESS:	
		STREET 1:		3737 MARKET STREET
		STREET 2:		SUITE 1300
		CITY:			PHILADELPHIA
		STATE:			PA
		ZIP:			19104

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PRICE T ROWE ASSOCIATES INC /MD/
		CENTRAL INDEX KEY:			0000080255
		STANDARD INDUSTRIAL CLASSIFICATION:	SECURITY & COMMODITY BROKERS, DEALERS, EXCHANGES & SERVICES [6200]
		IRS NUMBER:				520556948
		STATE OF INCORPORATION:			MD
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		100 EAST PRATT ST
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21202
		BUSINESS PHONE:		(410)345-6603

	MAIL ADDRESS:	
		STREET 1:		P.O. BOX 89000
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21289
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>once13gadec18.txt
<TEXT>
Document 1 - file: once13gadec18.txt

</DOCUMENT>
</SEC-DOCUMENT>