Stock Compensation (Tables)

12 Months Ended

Dec. 31, 2020

Schedule of Stock-based Compensation Expense

The following table sets forth the total stock-based compensation expense resulting from stock options and restricted stock included in our Consolidated Statements of Operations for the years ended December 31, 2020 and 2019:

	Years Ended December 31,
	2020		2019
Research and development – employee	$	—	$	(2,672	)
General and administrative – employee		327,854		1,953,274
Total employee stock-based compensation	$	327,854	$	1,950,602
General and administrative – non-employee	$	—	$	54,500
Total non-employee stock-based compensation	$	—	$	54,500

Schedule of Ranges of Stock Options

The following table summarizes significant ranges of outstanding stock options under the two plans at December 31, 2020:

Range of Exercise Prices	Number of Options		Weighted-Average Remaining Contractual Life (years)		Weighted-Average Exercise Price		Number of Options Exercisable		Weighted-Average Remaining Contractual Life (years)		Weighted-Average Exercise Price
$0.26 - $1.00		850,000		8.95	$	0.26		850,000		8.95	$	0.26
$1.01 – $3.00		1,050,673		6.60	$	2.04		1,050,673		6.60	$	2.04
$3.01 – $15.00		852,360		3.97	$	12.56		852,360		3.97	$	12.56
$15.01 –$42.42		413,237		3.09	$	25.29		413,237		3.09	$	25.29
		3,166,270		6.07	$	7.43		3,166,270		6.07	$	7.43

Schedule of Warrants Activity and Related Information

A summary of the Company’s warrant activity and related information for the years ended December 31, 2020 and 2019 are shown below.

	Warrants					Weighted Average Exercise Price
	2020		2019			2020		2019
Outstanding — beginning of year		193,916		693,916		$	8.60	$	7.16
Granted		—		—			—		—
Exercised		—		—			—		—
Forfeited		—		—			—		—
Expired		—		(500,000	)		—		6.60
Outstanding — end of year		193,916		193,916			8.60		8.60
Exercisable at end of year		193,916		193,916		$	8.60	$	8.60
Weighted average fair value of warrants granted during the year:	$	—	$	—

Schedule of Warrants

The following table summarizes additional information concerning warrants outstanding and exercisable at December 31, 2020:

Exercise Prices	Number of Shares		Weighted Average Remaining Contractual Life (years)		Weighted Average Exercise Price
$4.62		84,554		0.10	$	4.62
$10.44		83,335		0.11		10.44
$12.30		21,140		0.10		12.30
$33.60		4,167		3.21		33.60
		193,196		0.17	$	8.60

Employees and Directors [Member]

Schedule of Share-based Payment Award, Fair Value of the Stock Options Granted, Assumptions

There were no stock options issued to employees and directors in 2020. For the year ended December 31, 2019 the fair value of the stock options at the date of grant was estimated using the Black-Scholes option-pricing model, based on the following assumptions:

	2019
Risk-free interest rate		1.82	%
Expected volatility		85	%
Expected lives (years)		10
Expected dividend yield		0.00	%

Schedule of Stock Options Activity

There were no options granted to employees and directors during the year ended December 31, 2020. Presented below is the Company’s stock option activity for employees and directors:

	Stock Options						Weighted Average Exercise Price
	2020			2019			2020		2019
Outstanding — beginning of year		7,126,340			2,190,826		$	11.55	$	11.55
Granted		—			5,150,000			0.26		0.26
Exercised		(4,300,000	)		—			0.26		—
Forfeited		—			(186,512	)		9.49		9.49
Expired		(25,070	)		(27,974	)		41.03		43.30
Outstanding — end of year		2,801,270			7,126,340			7.68		3.32
Exercisable at end of year		2,801,270			7,034,242		$	7.68	$	3.34
Weighted average fair value of stock options granted during the year:	$	—		$	0.22

Non Employees [Member]

Schedule of Share-based Payment Award, Fair Value of the Stock Options Granted, Assumptions

For the year ended December 31, 2019 the fair value of the stock options granted to non-employees at the date of grant was estimated using the Black-Scholes option-pricing model, based on the following assumptions:

	2020		2019
Risk-free interest rate		—		1.82	%
Expected volatility		—		85	%
Expected lives (years)		—		10
Expected dividend yield		—		—

Schedule of Stock Options Activity

At December 31, 2020, there was no unrecognized compensation expense related to unvested non-employee stock options. Presented below is the Company’s non-employee stock option activity:

	Stock Options					Weighted Average Exercise Price
	2020			2019		2020		2019
Outstanding — beginning of year		615,000			365,000	$	3.36	$	5.49
Granted		—			250,000		—		0.26
Exercised		(250,000	)		—		0.26		—
Expired/Forfeited		—			—		0		—
Outstanding — end of year		365,000			615,000		5.49		3.36
Exercisable at end of year		365,000			365,000	$	5.49	$	3.36
Weighted average fair value of stock options granted during the year:	$	—		$	0.22