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Stock Based Compensation (Tables)
9 Months Ended
Sep. 30, 2019
Share-based Payment Arrangement [Abstract]  
Schedule of Total Stock-based Compensation Expense from Stock Options, Restricted Stock and Warrants

The following table sets forth the total stock-based compensation expense resulting from stock options and warrants included in our Condensed Consolidated Statements of Operations:

 

    Three Months Ended September 30,     Nine Months Ended September 30,  
    2019     2018     2019     2018  
Research and development — employee   $     $ 28,683     $ (2,672 )   $ 89,105  
General and administrative — employee     216,234       243,673       644,113       799,832  
Total employee stock-based compensation   $ 216,234     $ 272,356     $ 641,441     $ 888,937  
                                 
Research and development — non-employee   $     $     $     $  
General and administrative — non-employee   $       19,517             60,384  
Total non-employee stock-based compensation   $     $ 19,517     $     $ 60,384  

Schedule of Share-based Payment Award, Fair Value of the Stock Options Granted, Assumptions

The fair value of the stock options was estimated using the Black-Scholes option-pricing model, based on the following assumptions:

 

    Nine Months Ended September 30, 2019     Nine Months Ended September 30, 2018  
Risk-free interest rate           2.42 %
Expected volatility           91.6 %
Expected lives (years)           6  
Expected dividend yield           0.00 %

Schedule of Share-based Compensation, Stock Options, Activity

Presented below is our stock option activity:

 

    Nine Months Ended September 30, 2019  
    Number of Options (Employees)     Number of Options (Non-Employees)     Total Number
of Options
    Weighted-Average Exercise Price  
Outstanding at January 1, 2019     2,190,835       365,000       2,555,835     $ 10.69  
Granted                     $  
Exercised, Forfeited or Expired     (181,837 )           (181,837 )   $ 10.66  
Outstanding at September 30, 2019     2,008,998       365,000       2,373,998     $ 10.69  
Options exercisable at September 30, 2019     1,857,291       365,000       2,222,291     $ 11.29  

Schedule of Outstanding Stock Options

The following table summarizes significant ranges of outstanding stock options under our plans at September 30, 2019:

 

Range of
Exercise Prices
    Total Number of Options     Weighted-Average Remaining Contractual Life (years)     Weighted-Average Exercise Price     Total Number of Options Exercisable     Weighted-Average Remaining Contractual Life (years)     Weighted-Average Exercise Price  
$ 0.77 - $5.00       1,123,449       7.84     $ 2.13       971,743       7.81     $ 2.16  
$ 5.01 – $11.00       165,834       3.19     $ 10.98       165,834       3.19     $ 10.98  
$ 11.01 – $15.00       623,193       5.54     $ 13.89       623,193       5.54     $ 13.89  
$ 15.01 – $98.28       461,523       3.96     $ 27.09       461,523       3.96     $ 27.09  
          2,373,998       6.16     $ 10.69       2,222,291       6.03     $ 11.29