Stock Options and Equity-Classified Warrants - Schedule of Share-based Compensation, Stock Options, Activity (Details) - Stock Options [Member] - $ / shares	12 Months Ended
Dec. 31, 2018	Dec. 31, 2017
Employees and Directors [Member]
Number of Options Outstanding at beginning of period	2,492,179	2,813,280
Number of Options Granted	1,667	591,369
Number of Options Exercised		(19,213)
Number of Options Forfeited	(275,085)	(874,210)
Number of Options Expired	(27,935)	(19,047)
Number of Options Outstanding at end of period	2,190,835	2,492,179
Number of Options exercisable at end of period	1,887,387	1,701,445
Weighted average fair value of stock options granted	$ 1.43	$ 1.47
Weighted-Average Exercise Price Options Outstanding at beginning of period	11.35	14.14
Weighted-Average Exercise Price Options Granted	1.89	1.87
Weighted-Average Exercise Price Options Exercised		2.58
Weighted-Average Exercise Price Options Forfeited	7.64	13.11
Weighted-Average Exercise Price Options Expired	31.87	56.88
Weighted-Average Exercise Price Options Outstanding at end of period	11.55	11.35
Weighted-Average Exercise Price Options exercisable at end of period	$ 13.08	$ 14.85
Non Employees [Member]
Number of Options Outstanding at beginning of period	373,333	100,000
Number of Options Granted		273,333
Number of Options Exercised
Number of Options Expired/Forfeited	(8,333)
Number of Options Outstanding at end of period	365,000	373,333
Number of Options exercisable at end of period	365,000	373,333
Weighted average fair value of stock options granted		$ 1.54
Weighted-Average Exercise Price Options Outstanding at beginning of period	5.70	16.41
Weighted-Average Exercise Price Options Granted		1.78
Weighted-Average Exercise Price Options Exercised
Weighted-Average Exercise Price Options Expired/Forfeited	14.70
Weighted-Average Exercise Price Options Outstanding at end of period	5.49	5.70
Weighted-Average Exercise Price Options exercisable at end of period	$ 5.49	$ 5.70

The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.

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The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan.

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Number of options or other stock instruments for which the right to exercise has lapsed under the terms of the plan agreements.

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For presentations that combine terminations, the number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan or that expired.

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Weighted average price of options that were either forfeited or expired.

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The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan.

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Net number of share options (or share units) granted during the period.

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The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.

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Number of options outstanding, including both vested and non-vested options.

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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Weighted average price at which option holders acquired shares when converting their stock options into shares.

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Weighted average price at which grantees could have acquired the underlying shares with respect to stock options of the plan that expired.

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Weighted average price at which grantees could have acquired the underlying shares with respect to stock options that were terminated.

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Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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Number of share options (or share units) exercised during the current period.

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