-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 DLWDOn2LNQpHvKyNXMIStxc/ZzUtoU2Cp2Bb3pOoYb4T/i/eLLuPP3yabKE3a9fq
 YJUA7L38h5CRW5chsJOqiQ==

<SEC-DOCUMENT>0001250853-08-000097.txt : 20081124
<SEC-HEADER>0001250853-08-000097.hdr.sgml : 20081124
<ACCEPTANCE-DATETIME>20081124175827
ACCESSION NUMBER:		0001250853-08-000097
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20081121
FILED AS OF DATE:		20081124
DATE AS OF CHANGE:		20081124

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Wieland Douglas Scott
		CENTRAL INDEX KEY:			0001450614

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-15327
		FILM NUMBER:		081211546

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		949-582-2548

	MAIL ADDRESS:	
		STREET 1:		26826 SALINAS LANE
		CITY:			MISSION VIEHO
		STATE:			CA
		ZIP:			92691

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CYTRX CORP
		CENTRAL INDEX KEY:			0000799698
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				581642750
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		11726 SAN VICENTE BOULEVARD
		STREET 2:		SUITE 650
		CITY:			LOS ANGELES
		STATE:			CA
		ZIP:			90049
		BUSINESS PHONE:		310-826-5648

	MAIL ADDRESS:	
		STREET 1:		11726 SAN VICENTE BOULEVARD
		STREET 2:		SUITE 650
		CITY:			LOS ANGELES
		STATE:			CA
		ZIP:			90049
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>primary_doc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2008-11-21</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000799698</issuerCik>
        <issuerName>CYTRX CORP</issuerName>
        <issuerTradingSymbol>CYTR</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001450614</rptOwnerCik>
            <rptOwnerName>Wieland Douglas Scott</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>11726 SAN VICENTE BLVD., SUITE 650</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LOS ANGELES</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>90049</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Sr. VP - Drug Development</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>4.08</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2017-05-22</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>100000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>3.61</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <value>2017-12-04</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>25000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.57</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F3"/>
            </exerciseDate>
            <expirationDate>
                <value>2018-06-30</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>30000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.37</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F4"/>
            </exerciseDate>
            <expirationDate>
                <value>2018-11-20</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>50000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Stock Option vests in three equal annual installments beginning May 30, 2008, provided the Reporting Person remains in continuous employ of Issuer.</footnote>
        <footnote id="F2">Stock Option vests in three equal annual installments beginning December 6, 2008, provided the Reporting Person remains in continuous employ of Issuer.</footnote>
        <footnote id="F3">Stock Option vests in three equal annual installments beginning July 1, 2009, provided the Reporting Person remains in continuous employ of Issuer.</footnote>
        <footnote id="F4">Stock Option vests monthly over three years beginning December 21, 2008, provided the Reporting Person remains in continuous employ of Issuer.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ D. Scott Wieland</signatureName>
        <signatureDate>2008-11-24</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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