-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 HRlt6zp0Wpkt6AlcuKeriYaViM+8hba972tYBNsCTitEYoakjFK6xryFMIHPw7t7
 hTkA81EZNq6BbQoQgBjHKA==

<SEC-DOCUMENT>0001250853-04-000059.txt : 20040728
<SEC-HEADER>0001250853-04-000059.hdr.sgml : 20040728
<ACCEPTANCE-DATETIME>20040727185442
ACCESSION NUMBER:		0001250853-04-000059
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20040720
FILED AS OF DATE:		20040727

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Natalizio Matt
		CENTRAL INDEX KEY:			0001297706

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-15327
		FILM NUMBER:		04934240

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		310-826-5648

	MAIL ADDRESS:	
		STREET 1:		11726 SAN VICENTE BLVD., SUITE 650
		CITY:			LOS ANGELES
		STATE:			CA
		ZIP:			90049

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CYTRX CORP
		CENTRAL INDEX KEY:			0000799698
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				581642750
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		11726 SAN VICENTE BOULEVARD
		STREET 2:		SUITE 650
		CITY:			LOS ANGELES
		STATE:			CA
		ZIP:			90049
		BUSINESS PHONE:		310-826-5648

	MAIL ADDRESS:	
		STREET 1:		11726 SAN VICENTE BOULEVARD
		STREET 2:		SUITE 650
		CITY:			LOS ANGELES
		STATE:			CA
		ZIP:			90049
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>primary_doc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2004-07-20</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000799698</issuerCik>
        <issuerName>CYTRX CORP</issuerName>
        <issuerTradingSymbol>cytr</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001297706</rptOwnerCik>
            <rptOwnerName>Natalizio Matt</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>11726 SAN VICENTE BLVD., SUITE 650</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LOS ANGELES</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>90049</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Financial Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>1.11</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2014-07-11</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>100000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Stock Option vests in three equal instalments beginning July 12, 2005.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Matt Natalizio</signatureName>
        <signatureDate>2004-07-23</signatureDate>
    </ownerSignature>
</ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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