EXHIBIT 23.3

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the reference to our firm under the caption “Experts” in Post-Effective Amendment No. 1 on Form S-3 to the Registration Statement (Form S-3 No. 333-120208) and related Prospectus of Cytrx Corporation for the registration of 5,005,000 shares of its common stock and to the incorporation by reference therein of our report dated March 25, 2003, with respect to the consolidated financial statements and schedule of Cytrx Corporation for the year ended December 31, 2002, included in its Annual Report (Form 10-K) for the year ended December 31, 2004, filed with the Securities and Exchange Commission.

/s/ ERNST & YOUNG LLP

Atlanta, Georgia
April 7, 2005