March 27, 2018

VIA EDGAR

Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C.  20549-6010

Re: Registration Statement on Form S-3; File No. 333-223808

Ladies and Gentlemen:

In accordance with Rule 461 under the Securities Act of 1933, as amended, CytRx Corporation, a Delaware corporation, hereby requests that the Securities and Exchange Commission issue an order declaring the above-referenced Registration Statement effective at 5:00 P.M., Washington, D.C. time, on Monday, April 2, 2018, or as soon thereafter as is practicable.  Please call our counsel, Dale Short, at 310-789-1259 to inform him of the effectiveness.

Very truly yours,

/s/ STEVEN A.KRIEGSMAN

Steven A. Kriegsman

Chairman and Chief Executive Officer