10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

Form 10-Q

R QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended June 30, 2013

OR

£ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from ____________ to ____________

Commission file number 0-15327

CytRx Corporation

(Exact name of Registrant as specified in its charter)

Delaware	58-1642740
(State or other jurisdiction of incorporation or organization)	(I.R.S. Employer Identification No.)

11726 San Vicente Blvd., Suite 650 Los Angeles, CA	90049
(Address of principal executive offices)	(Zip Code)

(310) 826-5648

(Registrant’s telephone number, including area code)

Indicate by check mark whether the Registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the Registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.  Yes R     No £

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files). Yes R  No £

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. (Check one):

Large accelerated filer £	Accelerated filer R	Non-accelerated filer £	Smaller reporting company £
	(Do not check if a smaller reporting company)

Indicate by check mark whether the Registrant is a shell company (as defined in Rule 12(b)-2 of the Exchange Act).  Yes £     No R

Number of shares of CytRx Corporation common stock, $.001 par value, outstanding as of August 6, 2013: 30,489,556 shares exclusive of treasury shares.

CYTRX CORPORATION

FORM 10-Q

TABLE OF CONTENTS

	Page
PART I. — FINANCIAL INFORMATION
Item 1.Financial Statements	1
Item 2.Management’s Discussion and Analysis of Financial Condition and Results of Operations	8
Item 3.Quantitative and Qualitative Disclosures About Market Risk	13
Item 4.Controls and Procedures	13
PART II. — OTHER INFORMATION
Item 2.Unregistered Sales of Equity Securities and Use of Proceeds	13
Item 5.Other Information	14
Item 6.Exhibits	14
SIGNATURES	15
INDEX TO EXHIBITS	16

PART I — FINANCIAL INFORMATION

Item 1. — Financial Statements

CYTRX CORPORATION

CONDENSED BALANCE SHEETS

(Unaudited)

	June 30, 2013			December 31, 2012
ASSETS
Current assets:
Cash and cash equivalents	$	10,980,486		$	14,344,088
Short-term investments		17,000,000			24,000,000
Receivables		211,626			109,802
Interest receivable		56,451			26,517
Prepaid expenses and other current assets		580,904			1,212,041
Total current assets		28,829,467			39,692,448
Equipment and furnishings, net		199,580			253,277
Goodwill		183,780			183,780
Other assets		102,271			102,271
Total assets	$	29,315,098		$	40,231,776
LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities:     Accounts payable	$	2,783,894		$	3,060,516
Accrued expenses and other current liabilities		2,811,770			3,033,189
Warrant liabilities		3,133,743			3,972,230
Total current liabilities		8,729,407			10,065,935
Commitments and contingencies
Stockholders’ equity
Preferred Stock, $.01 par value, 5,000,000 shares authorized, including 25,000 shares of Series A Junior Participating Preferred Stock; no shares issued and outstanding		—			—
Common stock, $.001 par value, 250,000,000 shares authorized;  30,608,392shares issued and outstanding at June 30, 2013 and 30,607,916 at December 31, 2012		30,609			30,608
Additional paid-in capital		262,082,318			261,318,638
Treasury stock, at cost (118,836 shares at June 30, 2013 and 90,546 at December 31, 2012)		(2,335,818	)		(2,279,238	)
Accumulated deficit		(239,191,418	)		(228,904,167	)
Total stockholders’ equity		20,585,691			30,165,841
Total liabilities and stockholders’ equity	$	29,315,098		$	40,231,776

The accompanying notes are an integral part of these condensed financial statements.

1

CYTRX CORPORATION

CONDENSED STATEMENTS OF OPERATIONS

(Unaudited)

	Three Months Ended June 30,						Six Months Ended June 30,
	2013			2012			2013			2012
Revenue:
License revenue	$	200,000		$	—		$	200,000		$	—
Expenses:
Research and development		4,626,244			2,686,465			7,815,003			7,087,980
General and administrative		1,970,930			2,091,856			3,788,255			4,006,572
		6,597,174			4,778,321			11,603,258			11,094,552
Loss before other income (loss)		(6,397,174	)		(4,778,321	)		(11,403,258	)		(11,094,552	)
Other income (loss):
Interest income		35,564			27,547			75,822			63,005
Other income, net		4,761			16,491			201,698			50,551
Gain (loss) on warrant derivative liability		2,933,707			(8,528,192	)		838,487			(12,416,358	)
Net loss	$	(3,423,142	)	$	(13,262,475	)	$	(10,287,251	)	$	(23,397,354	)
Basic and diluted net loss per share	$	(0.11	)	$	(0.63	)	$	(0.34	)	$	(1.10	)
Basic and diluted  weighted average shares outstanding		30,418,435			21,204,499			30,417,906			21,203,754

The accompanying notes are an integral part of these condensed financial statements

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CYTRX CORPORATION

CONDENSED STATEMENTS OF CASH FLOWS

(Unaudited)

	Six Months Ended June 30,
	2013			2012
Cash flows from operating activities:
Net loss	$	(10,287,251	)	$	(23,397,354	)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization		59,226			52,875
Retirement of fixed assets		—			4,360
Stock compensation and warrant expense		762,748			858,937
Fair value adjustment on warrant liability		(838,487	)		12,416,358
Net foreign exchange gain		(138,709	)		—
Changes in assets and liabilities:
Receivables		(101,824	)		154,946
Interest receivable		(29,934	)		19,105
Prepaid expenses and other current assets		631,137			102,323
Accounts payable		(278,151	)		93,663
Accrued expenses and other current liabilities		(139,290	)		616,083
Net cash used in operating activities		(10,360,535	)		(9,078,704	)
Cash flows from investing activities:
Proceeds from sale of short-term investments		7,000,000			2,989,902
Purchases of equipment and furnishings		(4,000	)		(47,979	)
Net cash provided by investing activities		6,996,000			2,941,923
Cash flows from financing activities:
Net proceeds from exercise of stock options		933			7,200
Net cash provided by financing activities		933			7,200
Net decrease in cash and cash equivalents		(3,363,602	)		(6,129,581	)
Cash and cash equivalents at beginning of period		14,344,088			17,988,590
Cash and cash equivalents at end of period	$	10,980,486		$	11,859,009
Supplemental disclosure of cash flow information:
Equipment and furnishings purchased on credit	$	1,529		$	64,022
Repurchase of Company’s own stock for treasury	$	56,580			—
Cash paid for income taxes	$	5,600		$	82,110

The accompanying notes are an integral part of these condensed financial statements.

3

NOTES TO CONDENSED FINANCIAL STATEMENTS

June 30, 2013

(Unaudited)

1.  Description of Company and Basis of Presentation

CytRx Corporation (“CytRx” or the “Company”) is a biopharmaceutical research and development company specializing in oncology.  The CytRx oncology pipeline is focused on the clinical development of aldoxorubicin (formerly known as INNO-206), its improved version of the widely used chemotherapeutic agent doxorubicin. CytRx has reached targeted enrollment in an international Phase 2b clinical trial with aldoxorubicin as a treatment for soft tissue sarcomas and completed a Phase 1b/2 clinical trial primarily in the same indication and a Phase 1b study of aldoxorubicin in combination with doxorubicin in patients with advanced solid tumors. CytRx also is conducting a Phase 1b pharmacokinetics clinical trial of aldoxorubicin in patients with metastatic solid tumors. The Company is initiating a Phase 3 pivotal trial under a special protocol assessment (SPA) with aldoxorubicin as a therapy for patients with soft tissue sarcomas whose tumors have progressed following treatment with chemotherapy. CytRx may seek to expand its pipeline of oncology candidates based on a novel linker platform technology used in aldoxorubicin that can be utilized with multiple chemotherapeutic agents and may allow for greater concentration of the agents at tumor sites. The Company also has rights to two additional drug candidates, tamibarotene and bafetinib. The Company completed its evaluation of bafetinib in the ENABLE Phase 2 clinical trial in high-risk B-cell chronic lymphocytic leukemia (B-CLL), and plans to seek a partner for further development. CytRx is evaluating plans for further development of tamibarotene.

The accompanying condensed financial statements at June 30, 2013 and for the three-month and six-month periods ended June 30, 2013 and 2012 are unaudited, but include all adjustments, consisting of normal recurring entries, that management believes to be necessary for a fair presentation of the periods presented. Prior period figures have been reclassified, wherever necessary, to conform to current presentation. Interim results are not necessarily indicative of results for a full year. Balance sheet amounts as of December 31, 2012 have been derived from the Company’s audited financial statements as of that date.

The financial statements included herein have been prepared by the Company pursuant to the rules and regulations of the Securities and Exchange Commission (“SEC”). Certain information and footnote disclosures normally included in financial statements prepared in accordance with accounting principles generally accepted in the United States of America have been condensed or omitted pursuant to such rules and regulations. The financial statements should be read in conjunction with the Company’s audited financial statements contained in its Annual Report on Form 10-K for the year ended December 31, 2012. The Company’s operating results will fluctuate for the foreseeable future. Therefore, period-to-period comparisons should not be relied upon as predictive of the results in future periods.

Effective May 15, 2012, the Company completed a 1-for-7 reverse stock split of the Company’s outstanding shares of common stock; no change was made to the per-share par value per share of the common stock or to the number of shares of authorized common stock. All share and per share amounts in the accompanying consolidated financial statements have been adjusted to reflect the reverse stock split as if it had occurred at the beginning of the earliest period presented.

2.  Recent Accounting Pronouncements

We have reviewed all of the recent accounting pronouncements and have determined that they have not or will not have a material impact on our financial statements, or simply do not apply to our operations.

3.  Short-term Investments

The Company held $17.0 million of short-term investments at June 30, 2013.  The Company has classified these investments as available for sale.  These investments are federally insured certificates of deposit and have a maturity date of October 31, 2013.

4.  Investment in Mast Therapeutics, Inc.

On April 8, 2011, Mast Therapeutics, Inc. (formerly ADVENTRX Pharmaceuticals) completed its acquisition of SynthRx, Inc., in which the Company held a 19.1% interest. As a result of the transaction, the Company received approximately 126,000 shares of common stock of Mast Therapeutics, which it sold on October 11, 2011 for $112,200, and in June 2012, the Company received an additional 38,196 shares of common stock of Mast Therapeutics that had been held in an escrow established in connection with the acquisition, which it sold on June 6, 2012 for $17,900. In January 2013, the Company received an additional 92,566 shares, and in June 2013, an additional 47,745 shares, which were all sold in June 2013 for $60,566. If all of the development milestones under the acquisition agreement were to be achieved, the Company also would be entitled to receive up to 2.8 million additional Mast Therapeutics shares. Our former interest in SynthRx had a zero carrying value.

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5. Basic and Diluted Net Loss Per Common Share

Basic and diluted net loss per common share is computed based on the weighted-average number of common shares outstanding. Common share equivalents (which consist of options, warrants and restricted stock) are excluded from the computation of diluted net income (loss) per common share where the effect would be anti-dilutive.  Common share equivalents that could potentially dilute net income (loss) per share in the future, and which were excluded from the computation of diluted loss per share, totaled 11.2 million shares  for the three-month and six-month periods ended June 30, 2013, and 9.6 million shares for the three-month and six-month periods ended June 30, 2012.

6. Warrant Liabilities

Liabilities measured at market value on a recurring basis include warrant liabilities resulting from the Company’s past equity financings, including the underwritten public offering that closed on August 1, 2011.  In accordance with ASC 815-40, Derivatives and Hedging – Contracts in Entity’s Own Equity (“ASC 815-40”), the warrant liabilities are being marked to market until they are completely settled.  The warrants are valued using the Black-Scholes method, using assumptions consistent with our application of ASC 505-50, Equity-Based Payments to Non-Employees (“ASC 505-50”).  The gain or loss resulting from the marked to market calculation is shown on the Consolidated Statements of Operations as gain (loss) on warrant derivative liability. The Company recognized a gain (loss) of $2.9 million and ($8.5) million for the three-month periods ended June 30, 2013 and 2012, respectively, and a gain (loss) of $0.8 million and ($12.4) million for the six-month periods ended June 30, 2013 and 2012, respectively. The following reflects the weighted-average assumptions for each of the six-month periods indicated:

	Six Months Ended June 30,
	2013			2012
Risk-free interest rate		0.63	%		0.54	%
Expected dividend yield		0	%		0	%
Expected lives		2.96			3.90
Expected volatility		67.3	%		86.3	%
Warrants classified as liabilities	$	3,133,743		$	19,155,292
Gain (loss) on warrant liabilities	$	838,487		$	(12,416,358)

The dividend yield assumption of zero is based upon the fact that the Company has never paid and presently has no intention of paying cash dividends. The risk-free interest rate used for each warrant classified as a derivative is equal to the U.S. Treasury rates in effect at June 30th. The expected lives are based on the remaining contractual lives of the related warrants at the valuation date.

7.  Stock Based Compensation

The Company has a 2000 Long-Term Incentive Plan.  As of June 30, 2013, there were approximately 1.0 million shares subject to outstanding stock options under this plan, which expired on August 6, 2010.  Thus, no further shares are available for future grant under this plan.

The Company also has a 2008 Stock Incentive Plan.  As of June 30, 2013, there were 2.4 million shares subject to outstanding stock options and 2.6 million shares available for future grant under this plan.

The Company follows ASC 718, Compensation-Stock Compensation, which requires the measurement and recognition of compensation expense for all stock-based awards made to employees.

For stock options and stock warrants paid in consideration of services rendered by non-employees, the Company recognizes compensation expense in accordance with the requirements of ASC 505-50.

Non-employee option grants that do not vest immediately upon grant are recorded as an expense over the vesting period. At the end of each financial reporting period, the value of these options, as calculated using the Black-Scholes option-pricing model, is determined, and compensation expense recognized or recovered during the period is adjusted accordingly. Since the fair market value of options granted to non-employees is subject to change in the future, the amount of the future compensation expense is subject to adjustment until the common stock options are fully vested.

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The following table sets forth the total stock-based compensation expense resulting from stock options and warrants included in the Company’s unaudited interim statements of operations:

	Three Months Ended June 30,				Six Months Ended June 30,
	2013		2012		2013		2012
Research and development — employee	$	53,583	$	98,242	$	103,755	$	193,366
General and administrative — employee		202,589		263,007		387,229		437,079
Total employee stock-based compensation	$	256,172	$	361,249	$	490,984	$	630,445
Research and development — non-employee	$	—	$	—	$	—	$	—
General and administrative — non-employee		152,074		176,074		179,286		228,492
Total non-employee stock-based compensation	$	152,074	$	176,074	$	179,286	$	228,492

During the six-month period ended June 30, 2013, the Company issued stock options to purchase 117,176 shares of its common stock. The fair value of the stock options granted in the current six-month period was estimated using the Black-Scholes option-pricing model, based on the following assumptions:

	Six Months Ended June 30, 2013			Six Months Ended June 30, 2012
Risk-free interest rate		1.11	%		1.54	%
Expected volatility		85.2% - 85.8	%		89.7% - 97.7	%
Expected lives (years)		6			6 - 10
Expected dividend yield		0.00	%		0.00	%

The Company’s computation of expected volatility is based on the historical daily volatility of its publicly traded stock. For option grants issued during the six-month period ended June 30, 2013, the Company used a calculated volatility for each grant. The Company uses historical information to compute expected lives. In the six-month period ended June 30, 2013, the contractual term of the options granted was ten years and the Company used six years as the expected life. The dividend yield assumption of zero is based upon the fact the Company has never paid and presently has no intention of paying cash dividends. The risk-free interest rate used for each grant is equal to the U.S. Treasury rates in effect at the time of the grant for instruments with a similar expected life. Based on historical experience, for the six-month period ended June 30, 2013, the Company has estimated an annualized forfeiture rate of 12% for options granted to its employees, 3% for options granted to senior management and 0% for options granted to directors and non-employees. For the comparative six-month period ended June 30, 2012, the Company had estimated an annualized forfeiture rate of 14% for options granted to its employees, 2% for options granted to senior management and 0% for options granted to directors and non-employees. Compensation costs will be adjusted for future changes in estimated forfeitures. The Company will record additional expense if the actual forfeitures are lower than estimated and will record a recovery of prior expense if the actual forfeiture rates are higher than estimated. No amounts relating to employee stock-based compensation have been capitalized.

As of June 30, 2013, there remained approximately $1.3 million of unrecognized compensation expense related to unvested stock options granted to current and former employees, directors and consultants, to be recognized as expense over a weighted-average period of 1.13 years. Presented below is the Company’s stock option activity:

	Six Months Ended June 30, 2013
	Number of Options (Employees)			Number of Options (Non-Employees)		Total Number of Options			Weighted-Average Exercise Price
Outstanding at January 1, 2013		3,240,850			142,143		3,382,993		$	4.17
Granted		92,176			25,000		117,176		$	2.52
Exercised		(476	)		—		(476	)	$	1.96
Forfeited or expired		(103,716	)		—		(103,716	)	$	3.08
Outstanding at June 30, 2013		3,228,834			167,143		3,395,977		$	4.15
Options exercisable at June 30, 2013		2,159,480			149,881		2,309,361		$	5.10

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A summary of the unvested stock options as of June 30, 2013, and changes during the six-month period then ended, is presented below:

	Number of Options (Employees)			Number of Options (Non-Employees)			Total Number of Options			Weighted-Average Grant Date Fair Value per Share
Non-vested at January 1, 2013		1,322,389			8,929			1,331,318		$	1.69
Granted		92,176			25,000			117,176		$	1.80
Forfeited or expired		(103,716	)		—			(103,716	)	$	2.32
Vested		(241,495	)		(16,667	)		(258,162	)	$	3.68
Non-vested at June 30, 2013		1,069,354			17,262			1,086,616		$	1.67

The following table summarizes significant ranges of outstanding stock options under the Company’s plans at June 30, 2013:

Range of Exercise Prices		Number of Options		Weighted-Average Remaining Contractual Life (years)		Weighted-Average Exercise Price		Number of Options Exercisable		Weighted-Average Contractual Life		Weighted-Average Exercise Price
$	1.83 - 3.00		2,143,069		8.99	$	1.99		1,100,587		8.99	$	2.04
$	3.01 –7.00		178,512		4.77	$	5.24		176,036		4.77	$	5.26
$	7.01 –8.50		942,110		4.63	$	7.66		900,452		4.63	$	7.68
$	8.51 – 32.55		132,286		1.33	$	12.75		132,286		1.33	$	12.75
			3,395,977		7.26	$	4.15		2,309,361		7.26	$	5.10

The aggregate intrinsic value of outstanding options as of June 30, 2013 was $2.7 million, which represents options whose exercise price was less than the closing fair market value of the Company’s common stock on June 28, 2013 of $2.00.

Restricted Stock

On December 31, 2012, the Company granted to Dr. Daniel Levitt, Executive Vice President and Chief Medical Officer, 100,000 shares of CytRx Corporation restricted stock pursuant to the 2008 Plan, of which 50,000 shares vested on June 30, 2013, and the remaining 50,000 shares will vest in six subsequent monthly installments, provided that Dr. Levitt remains employed by the Company as of the end of each such month. The fair value of the restricted stock is based on the market price of the Company’s shares on the grant date less the par value received as consideration. The fair value of these restricted shares on the grant date was $186,900. The stock-based compensation expense relating to restricted stock for the three and six-months ended June 30, 2013, respectively, was $46,495 and $92,478.  There was no such expense in the comparable periods of 2012.

8. Fair Value Measurements

Assets and liabilities recorded at fair value on the balance sheets are categorized based upon the level of judgment associated with the inputs used to measure the fair value.  Level inputs are as follows:

Level 1 – quoted prices in active markets for identical assets or liabilities.

Level 2 – other significant observable inputs for the assets or liabilities through corroboration with market data at the measurement date.

Level 3 – significant unobservable inputs that reflect management’s best estimate of what market participants would use to price the assets or liabilities at the measurement date.

The following table summarizes fair value measurements by level at June 30, 2013 for assets and liabilities measured at fair value on a recurring basis:

(In thousands)	Level I		Level II		Level III		Total
Cash equivalents	$	10,384	$	—	$	—	$	10,384
Short-term investments		17,000		—		—		17,000
Warrant liability		—		—		3,134		3,134

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The following table summarizes fair value measurements by level at December 31, 2012 for assets and liabilities measured at fair value on a recurring basis:

(In thousands)	Level I		Level II		Level III		Total
Cash equivalents	$	13,188	$	—	$	—	$	13,188
Short-term investments		24,000		—		—		24,000
Warrant liabilities		—		—		3,972		3,972

Liabilities measured at market value on a recurring basis include warrant liabilities resulting from the Company’s July 2009 and August 2011 equity financings. In accordance with ASC 815-40, the warrant liabilities are marked to market each quarter-end until they are completely settled. The warrants are valued using the Black-Scholes method, using assumptions consistent with the Company’s application of ASC 505-50. See Warrant Liabilities above.

The Company considers carrying amounts of accounts receivable, accounts payable and accrued expenses to approximate fair value due to the short-term nature of these financial instruments.  

The Company’s non-financial assets are measured at fair value when there is an indicator of impairment and recorded at fair value only when an impairment charge is recognized.  The Company’s non-financial assets were not material at June 30, 2013 or 2012.

9.      Liquidity and Capital Resources

At June 30, 2013, the Company had cash and cash equivalents of approximately $11.0 million and short-term investments of $17.0 million.  Management believes that the Company’s current cash on hand and short-term investments will be sufficient to fund its operations for the foreseeable future.  The estimate is based, in part, upon the Company’s currently projected expenditures for the remainder of 2013 and the first six months of 2014 of approximately $20.7 million, whichincludes approximately $8.1 million for its clinical programs for aldoxorubicin, approximately $1.2 million for its clinical programs for tamibarotene and bafetinib, approximately $4.7 million for general operation of its clinical programs, and approximately $6.7 million for other general and administrative expenses. These projected expenditures are also based upon numerous other assumptions and subject to many uncertainties, and our actual expenditures may be significantly different from these projections.

If the Company obtains marketing approval and successfully commercializes its product candidates, the Company anticipates it will take severalyears, and possibly longer, for it to generate significant recurring revenue.  The Company will be dependent on future financing and possible strategic partnerships or asset sales until such time, if ever, as it can generate significant recurring revenue. The Company has no commitments from third parties to provide any additional financing, and it may not be able to obtain future financing on favorable terms, or at all. If the Company fails to obtain sufficient funding when needed, it may be forced to delay, scale back or eliminate all or a portion of its development programs or clinical trials, seek to license to other companies its product candidates or technologies that it would prefer to develop and commercialize itself, or seek to sell some or all of its assets or merge with or be acquired by another company.

10.      Income Taxes

The Company completed an analysis of changes in ownership and concluded the net operating loss carryforwards as of December 31, 2012 are not subject to limitation under Section 382 of the Internal Revenue Code. The Company will continue to monitor any possible changes in ownership.

Item 2. — Management’s Discussion and Analysis of Financial Condition and Results of Operations

Forward Looking Statements

From time to time, we make oral and written statements that may constitute “forward-looking statements” (rather than historical facts) as defined in the Private Securities Litigation Reform Act of 1995 or by the SEC in its rules, regulations and releases, including Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. We desire to take advantage of the “safe harbor” provisions in the Private Securities Litigation Reform Act of 1995 for forward-looking statements made from time to time, including, but not limited to, the forward-looking statements made in this Quarterly Report, as well as those made in our other filings with the SEC.

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All statements in this Quarterly Report, including statements in this section, other than statements of historical fact are forward-looking statements for purposes of these provisions, including statements of our current views with respect to the recent developments regarding our business strategy, business plan and research and development activities, our future financial results, and other future events. These statements include forward-looking statements both with respect to us, specifically, and the biotechnology industry, in general. In some cases, forward-looking statements can be identified by the use of terminology such as “may,” “will,” “expects,” “plans,” “anticipates,” “estimates,” “potential” or “could” or the negative thereof or other comparable terminology. Although we believe that the expectations reflected in the forward-looking statements contained herein are reasonable, there can be no assurance that such expectations or any of the forward-looking statements will prove to be correct, and actual results could differ materially from those projected or assumed in the forward-looking statements.

All forward-looking statements involve inherent risks and uncertainties, and there are or will be important factors that could cause actual results to differ materially from those indicated in these statements. We believe that these factors include, but are not limited to, the factors discussed in this section and under the caption “Risk Factors” in our Annual Report on Form 10-K for the year ended December 31, 2012, all of which should be reviewed carefully. If one or more of these or other risks or uncertainties materialize, or if our underlying assumptions prove to be incorrect, actual results may vary materially from what we anticipate. Please consider our forward-looking statements in light of those risks as you read this Quarterly Report. We undertake no obligation to publicly update or review any forward-looking statement, whether as a result of new information, future developments or otherwise.

Overview

CytRx Corporation (“CytRx,” the “Company,” “we,” “us” or “our”) is a biopharmaceutical research and development company specializing in oncology.  Our oncology pipeline is focused on the clinical development of aldoxorubicin (formerly known as INNO-206), our improved version of the widely used chemotherapeutic agent doxorubicin. We have reached targeted enrollment in an international Phase 2b clinical trial with aldoxorubicin as a treatment for soft tissue sarcomas and completed a Phase 1b/2 clinical trial primarily in the same indication and a Phase 1b study of aldoxorubicin in combination with doxorubicin in patients with advanced solid tumors.  We also are conducting a Phase 1b pharmacokinetics clinical trial of patients with metastatic solid tumors. We are initiating a Phase 3 pivotal trial under a special protocol assessment (SPA) with aldoxorubicin as a therapy for patients with soft tissue sarcomas whose tumors have progressed following treatment with chemotherapy. We may seek to expand our pipeline of oncology candidates based on a novel linker platform technology used in aldoxorubicin that can be utilized with multiple chemotherapeutic agents and may allow for greater concentration of the agents at tumor sites. We also have rights to two additional drug candidates, tamibarotene and bafetinib. We completed our evaluation of bafetinib in the ENABLE Phase 2 clinical trial in high-risk B-cell chronic lymphocytic leukemia (B-CLL), and plan to seek a partner for further development of bafetinib. We are evaluating plans for further development of tamibarotene.

Critical Accounting Policies and Estimates

Management’s discussion and analysis of our financial condition and results of operations are based on our financial statements, which have been prepared in accordance with accounting principles generally accepted in the U.S. The preparation of these financial statements requires management to make estimates and judgments that affect the reported amounts of assets, liabilities, revenue and expenses, and related disclosure of contingent assets and liabilities. On an ongoing basis, management evaluates its estimates, including those related to revenue recognition, impairment of long-lived assets, including finite-lived intangible assets, research and development expenses and clinical trial expenses and stock-based compensation expense.

We base our estimates on historical experience and on various other assumptions that are believed to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Actual results may differ materially from these estimates under different assumptions or conditions.

Our significant accounting policies are summarized in Note 2 to our financial statements contained in our Annual Report on Form 10-K for the year ended December 31, 2012. We believe the following critical accounting policies affect our more significant judgments and estimates used in the preparation of our financial statements:

Revenue Recognition

Revenue consists of license fees from strategic alliances with pharmaceutical companies, as well as service and grant revenues. Service revenueconsists of contract research and laboratory consulting. Grant revenuesconsist of government and private grants.

Monies received for license fees are deferred and recognized ratably over the performance period in accordance with Financial Accounting Standards Board (“FASB”) Accounting Codification Standards (“ASC”) ASC 605-25, Revenue Recognition – Multiple-Element Arrangements (“ASC 605-25”). Milestone payments will be recognized upon achievement of the milestone as long as the milestone is deemed substantive and we have no other performance obligations related to the milestone and collectability is reasonably assured, which is generally upon receipt, or recognized upon termination of the agreement and all related obligations. Deferred revenue represents amounts received prior to revenue recognition.

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Revenues from contract research, government grants, and consulting fees are recognized over the respective contract periods as the services are performed, provided there is persuasive evidence or an arrangement, the fee is fixed or determinable and collection of the related receivable is reasonably assured. Once all conditions of the grant are met and no contingencies remain outstanding, the revenue is recognized as grant fee revenue and an earned but unbilled revenue receivable is recorded.

Research and Development Expenses

Research and development expenses consist of direct and overhead-related research expenses and are expensed as incurred. Costs to acquire technologies, including licenses, that are utilized in research and development and that have no alternative future use are expensed when incurred. Costs of technology developed for use in our products are expensed as incurred until technological feasibility has been established.

Clinical Trial Expenses

Clinical trial expenses, which are included in research and development expenses, include obligations resulting from our contracts with various clinical research organizations in connection with conducting clinical trials for our product candidates. We recognize expenses for these activities based on a variety of factors, including actual and estimated labor hours, clinical site initiation activities, patient enrollment rates, estimates of external costs and other activity-based factors. We believe that this method best approximates the efforts expended on a clinical trial with the expenses we record. We adjust our rate of clinical expense recognition if actual results differ from our estimates. If our estimates are incorrect, clinical trial expenses recorded in future periods could vary.

Stock-Based Compensation

Our stock-based employee compensation plans are described in Note 7 of the Notes to Condensed Financial Statements included in this Quarterly Report. We follow ASC 718, Compensation-Stock Compensation (“ASC 718”), which requires the measurement and recognition of compensation expense for all stock-based awards made to employees.

For stock options and stock warrants paid in consideration of services rendered by non-employees, we recognize compensation expense in accordance with the requirements of ASC 505-50, Equity-Based Payments to Non-Employees (“ASC 505-50”).

Non-employee option grants that do not vest immediately upon grant are recorded as an expense over the vesting period. At the end of each financial reporting period prior to performance, the value of these options is determined using the Black-Scholes option-pricing model, and compensation expense recognized or recovered during the period is adjusted accordingly. Since the fair market value of options granted to non-employees is subject to change in the future, the amount of the future compensation expense is subject to adjustment until the common stock options or warrants are fully vested.

The fair value of each stock option grant is estimated using the Black-Scholes option-pricing model, which uses certain assumptions related to risk-free interest rates, expected volatility, expected life of the stock options and future dividends. Compensation expense is recorded based upon the value derived from the Black-Scholes option-pricing model, based on an expected forfeiture rate that is adjusted for our actual experience. If our Black-Scholes option-pricing model assumptions or our actual or estimated forfeiture rate are different in the future, it could materially affect our compensation expense recorded in future periods.

Impairment of Long-Lived Assets

We review long-lived assets, including finite-lived intangible assets, for impairment on an annual basis as of December 31, or on an interim basis if an event occurs that might reduce the fair value of such assets below their carrying values. An impairment loss would be recognized based on the difference between the carrying value of the asset and its estimated fair value, which would be determined based on either discounted future cash flows or other appropriate fair value methods. If our estimates used in the determination of either discounted future cash flows or other appropriate fair value methods are not accurate as compared to actual future results, we may be required to record an impairment charge.

Net Loss per Share

Basic and diluted net loss per common share is computed using the weighted-average number of common shares outstanding. Potentially dilutive stock options and warrants to purchase 11.2 million  shares for each of the three-month and six-month periods ended June 30, 2013, and 9.6 million shares for each of the three-month and six-month periods ended June 30, 2012, were excluded from the computation of diluted net loss per share, because the effect would be anti-dilutive.

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Warrant Liabilities

Liabilities measured at market value on a recurring basis include warrant liabilities resulting from our July 2009 and August 2011 equity financings. In accordance with ASC 815-40, Accounting for Derivative Financial Instruments Indexed to and Potentially Settled in a Company’s Own Stock (“ASC 815-40”), the warrant liabilities are marked to market each quarter-end until they are completely settled. The warrants are valued using the Black-Scholes method, using assumptions consistent with our application of ASC 505-50. The gain or loss resulting from the marked to market calculation is shown on the statements of operations as a gain or loss on warrant derivative liability.

Investment in Mast Therapeutics, Inc.

On April 8, 2011, Mast Therapeutics, Inc. (formerly “ADVENTRX Pharmaceuticals”) completed its acquisition of SynthRx, Inc., in which we held a 19.1% interest. As a result of the transaction, we received approximately 126,000 shares of common stock of Mast Therapeutics, which we sold on October 11, 2011 for $112,200, and in June 2012, we received an additional 38,196 shares of common stock of Mast Therapeutics that had been held in an escrow established in connection with the acquisition, which we sold on June 6, 2012 for $17,900.  In January 2013, we received an additional 92,566 shares, and in June 2013, an additional 47,745 shares, which were all sold in June 2013 for $60,566.If all of the development milestones under the acquisition agreement were to be achieved, we also would be entitled to receive up to 2.8 million additional Mast Therapeutics shares. At the time of the sale, our interest in SynthRx had a zero carrying value.

Liquidity and Capital Resources

We have relied primarily upon proceeds from sales of our equity securities and the exercise of options and warrants, and to a much lesser extent upon payments from our strategic partners and licensees, to generate funds needed to finance our business and operations.

At June 30, 2013, we had cash and cash equivalents of approximately $11.0 million and short term investments of $17.0 million.  Management believes that our current cash on hand and short-term investments will be sufficient to fund our operations for the foreseeable future.  The estimate is based, in part, upon our currently projected expenditures for the remainder of 2013 and the first six months of 2014 of approximately $20.7 million, whichincludes approximately $8.1 million for our clinical programs for aldoxorubicin, approximately $1.2 million for our clinical programs for tamibarotene and bafetinib, approximately $4.7 million for general operation of our clinical programs, and approximately $6.7 million for other general and administrative expenses. The projected expenditures are also based upon numerous other assumptions and subject to many uncertainties, and our actual expenditures may be significantly different from these projections.

If we obtain marketing approval and successfully commercialize one or more of our product candidates, we anticipate it will take severalyears and possibly longer, for us to generate significant recurring revenue. We will be dependent on future financing and possible strategic partnerships or asset sales until such time, if ever, as we can generate significant recurring revenue. We have no commitments from third parties to provide us with any additional financing, and we may not be able to obtain future financing on favorable terms, or at all.  If we fail to obtain sufficient funding when needed, we may be forced to delay, scale back or eliminate all or a portion of our development programs or clinical trials, seek to license to other companies our product candidates or technologies that we would prefer to develop and commercialize ourselves, or seek to sell some or all of our assets or merge with or be acquired by another company.

We recorded a net loss in the quarter ended June 30, 2013 of $3.4 million as compared to a net loss in the quarter ended June 30, 2012 of $13.3 million, or a decrease of $9.9 million, due principally to the recording of a gain of $2.9 million on warrant derivative liability in the current quarter, as compared to a loss on warrant derivative liability of $8.5 million in quarter ended June 30, 2012. This change was partially offset by an increase of approximately $1.9 million in our research and development expenditures in the current quarter as compared to the quarter ended June 30, 2012, due to the increase in expenditures associated with our clinical program for aldoxorubicin.

We received $7.0 million and $2.9 million of cash from investing activities in the six-month periods ended June 20, 2013 and 2012, respectively, from net proceeds from the sale of matured certificates of deposits. We utilized approximately $4,000 for capital expenditures in the six-month period ended June 30, 2013 as compared to approximately $48,000 in the comparable 2012 period. We do not expect any significant capital spending during the next 12 months.

We received $933 and $7,200 from the exercise of stock options in the six-month period ended June 30, 2013 and 2012, respectively.

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We continue to evaluate potential future sources of capital, as we do not currently have commitments from any third parties to provide us with additional capital. The results of our technology licensing efforts and the actual proceeds of any fund-raising activities will determine our ongoing ability to operate as a going concern. Our ability to obtain future financings through joint ventures, product licensing arrangements, royalty sales, equity financings, grants or otherwise is subject to market conditions and our ability to identify parties that are willing and able to enter into such arrangements on terms that are satisfactory to us. Depending upon the outcome of our fundraising efforts, the accompanying financial information may not necessarily be indicative of our future financial condition.

As a development company that is primarily engaged in research and development activities, we expect to incur significant losses and negative cash flow from operating activities for the foreseeable future.  There can be no assurance that we will be able to generate revenues from our product candidates and become profitable.  Even if we become profitable, we may not be able to sustain that profitability.

Results of Operations

We recorded a net loss of approximately $3.4 million and $10.3 million for the three-month and six-month periods ended June 30, 2013, respectively, as compared to a net loss of approximately $13.3 million and $23.4 million for the three-month and six-month periods ended June 30, 2012, respectively. The decrease in our net loss during the current three-month period resulted primarily from the recording of a gain of $2.9 million on warrant derivative liability in the current quarter, as compared to a loss on warrant derivative liability of $8.5 million in quarter ended June 30, 2012, for a difference of $11.4 million.

We recognized $200,000 of licensing revenue in the three-month period ended June 30, 2013, as compared to $0 for the quarter ended June 30, 2012. All future licensing fees under our current licensing agreements are dependent upon successful development milestones being achieved by the licensor. During the balance of 2013, we do not anticipate receiving any significant licensing fees.

Research and Development

	Three-Month Period Ended June 30,				Six-Month Period Ended June 30,
	2013		2012		2013		2012
	(In thousands)				(In thousands)
Research and development expenses	$	4,517	$	2,582	$	7,601	$	6,885
Employee stock option expense		100		98		196		193
Depreciation and amortization		9		6		18		10
	$	4,626	$	2,686	$	7,815	$	7,088

Research expenses are expenses incurred by us in the discovery of new information that will assist us in the creation and the development of new drugs or treatments. Development expenses are expenses incurred by us in our efforts to commercialize the findings generated through our research efforts.  Our research and development expenses, excluding stock option expense, and depreciation and amortization, were $4.5 million and $7.6 million for the three-month and six-month periods ended June 30, 2013, respectively, and $2.6 million and $6.9 million, respectively, for the same periods in June 30, 2012.

Research and development expenses incurred during the three-month and six-month periods ended June 30, 2013 relate to our various development programs.  In the three-month period ended June 30, 2013, the development expenses of our program for aldoxorubicin were $2.5 million and the expenses of our program for tamibarotene were $0.9 million. The remainder of our research and development expenses primarily related to research and development support costs.

General and Administrative Expenses

	Three-Month Period Ended June 30,				Six-Month Period Ended June 30,
	2013		2012		2013		2012
	(In thousands)				(In thousands)
General and administrative expenses	$	1,597	$	1,633	$	3,181	$	3,299
Non-cash general and administrative expenses		152		176		179		228
Employee stock option expense		202		263		387		437
Depreciation and amortization		20		20		41		43
	$	1,971	$	2,092	$	3,788	$	4,007

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General and administrative expenses include all administrative salaries and general corporate expenses, including legal expenses associated with the prosecution of our intellectual property. Our general and administrative expenses, excluding stock option expense, non-cash expenses and depreciation and amortization, were $1.6 million and $3.2 million for the three-month and six-month periods ended June 30, 2013, respectively, and $1.6 million and $3.3 million, respectively, for the same periods in 2012.

Employee stock option expense relates to options granted to retain and compensate directors, officers and other employees.  We recorded approximately $0.2 million and $0.4 million of employee stock option expense in the three-month and six-month periods ended June 30, 2013, respectively, as compared to $0.3 million  and $0.4 million, respectively, for the same periods in 2012. We recorded approximately $0.2 million of non-employee stock option expense in each of the three-month and six-month periods ended June 30, 2013, and each of the same periods in 2012.

Depreciation and Amortization

Depreciation expense reflects the depreciation of our equipment and furnishings.

Interest Income

Interest income was $36,000 and $76,000 for the three-month and six-month periods ended June 30, 2013, respectively, as compared to $28,000 and $63,000, respectively, for the same periods in 2012.

Item 3. — Quantitative and Qualitative Disclosures About Market Risk

Our exposure to market risk is limited primarily to interest income sensitivity, which is affected by changes in the general level of U.S. interest rates, particularly because a significant portion of our investments are in short-term debt securities issued by the U.S. government and institutional money market funds. The primary objective of our investment activities is to preserve principal. Due to the nature of our short-term investments, we believe that we are not subject to any material market risk exposure. We do not have any speculative or hedging derivative financial instruments or foreign currency instruments. If interest rates had varied by 10% in the three-month period ended June 30, 2013, it would not have had a material effect on our results of operations or cash flows for that period.

Item 4. — Controls and Procedures

Evaluation of Disclosure Controls and Procedures

Our management, with the participation of our Chief Executive Officer and our Chief Financial Officer, performed an evaluation of the effectiveness of the design and operation of our disclosure controls and procedures (as defined in Securities Exchange Act Rule 13a-15(e)) as of the end of the quarterly period covered by this Quarterly Report. Based on that evaluation, our Chief Executive Officer and our Chief Financial Officer concluded that our disclosure controls and procedures were effective to ensure that information required to be disclosed by us in reports that we file or submit under the Securities Exchange Act of 1934 is recorded, processed, summarized and reported within the time periods specified in the rules and forms of the SEC.

Changes in Controls over Financial Reporting

There was no change in our internal control over financial reporting that occurred during the quarter ended June 30, 2013 that materially affected, or is reasonably likely to materially affect, our internal control over financial reporting. We continually seek to assure that all of our controls and procedures are adequate and effective. Any failure to implement and maintain improvements in the controls over our financial reporting could cause us to fail to meet our reporting obligations under the SEC’s rules and regulations. Any failure to improve our internal controls to address the weaknesses we have identified could also cause investors to lose confidence in our reported financial information, which could have a negative impact on the trading price of our common stock.

PART II — OTHER INFORMATION

Item 2. — Unregistered Sales of Equity Securities and Use of Proceeds

In May 2013, we issued 5-year warrants to purchase a total of 66,667 shares of our common stock at an exercise price of $2.95 per share, in connection with financial advisory arrangements.  In August 2013, we issued a warrant to purchase a total of 500,000 shares of our common stock at an exercise price of $2.50 per share in connection with a financial advisory arrangement described under Item 5 below.  The issuance of these warrants was exempt from registration under the Securities Act of 1933 pursuant to Section 4(2) of the Securities Act of 1933.

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Item 5. — Other Information

On August 5, 2013, CytRx Corporation (the "Company") entered into an investment banking agreement with Legend Securities, Inc. (“Legend”), pursuant to which Legend agrees to continue to provide investor relations and business advisory services to us for a period of two years, which may be extended by us for up to an additional six months upon notice to Legend. In consideration for Legend’s services, we agreed to continue to pay Legend a monthly advisory fee of $30,000 and to issue Legend a warrant to purchase 500,000 shares of our common stock at an exercise price per share of $2.50. The warrant will vest as to 100,000 of the warrant shares upon issuance and as to an additional 100,000 of the warrant shares on each six-month anniversary of the date of the agreement, and will be exercisable for a period of five years. Under the investment banking agreement, we also agreed to give Legend “piggy back” registration rights with respect to the shares of our common stock underlying the warrant in any registration statement filed by us on behalf of holders of our securities in connection with resales of such securities by the holders.

Item 6. — Exhibits

The exhibits listed in the accompanying Index to Exhibits are filed as part of this Quarterly Report and incorporated herein by reference.

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

	CytRx Corporation
Date: August 6, 2013	By:	/s/ JOHN Y. CALOZ
		John Y. Caloz
		Chief Financial Officer

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INDEX TO EXHIBITS

Exhibit Number	Description
10.1	Investment Banking Agreement dated August 5, 2013, between CytRx Corporation and Legend Securities, Inc.
31.1	Certification of Chief Executive Officer Pursuant to 17 CFR 240.13a-14(a)
31.2	Certification of Chief Financial Officer Pursuant to 17 CFR 240.13a-14(a)
32.1	Certification of Chief Executive Officer Pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
32.2	Certification of Chief Financial Officer Pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
101.INS	XBRL Instance Document
101.SCH	XBRL Schema Document
101.CAL	XBRL Calculation Linkbase Document
101.DEF	XBRL Definition Linkbase Document
101.LAB	XBRL Label Linkbase Document
101.PRE	XBRL Presentation Linkbase Document

EX-10.1

Exhibit 10.1

Steven Kriegsman, CEO

CytRx Corp.

11726 San Vicente Blvd

Los Angeles, CA 90049

Phone: 310-826-5648

Fax: 310-826-6139

Re: Investment Banking Agreement with Legend Securities, Inc.

Dear Mr. Kriegsman,

This letter (the “Agreement”) shall confirm the engagement of Legend Securities, Inc., (“Legend”)by CytRx Corporation (the “Company”and collectively the “Parties” ) for purposes of providing, on a non-exclusive basis, investor awareness and business advisory services as set forth below in consideration for the fees and compensation described hereinafter:

1. The Agreement shall be effective as of the date it is executed by the Parties (the “Effective Date”).

2. The Company agrees to provide Legend such information, hisptorical financial data, projections, proformas, business plans, due dilligence documentation, and other information (collectively the “Information”) in the possession of the Company that Legend may reasonably request or require to perform the Services (as hereinafter defined) set forth herein. The Information provided by the Company to Legend shall be true, complete and accurate in all material respects as of the date specified therein and shall not set forth any untrue statements nor omit and fact required or necessary to make the Information provided not misleading; provided that Legend acknowledges and agrees that the Company shall not provide any information that the Company deems to be confidential. The Company authorizes Legend to use such Information soley in connection with its performance of the Services.

3. Legend will use its best efforts to furnish ongoing investor awareness and business advisory services (the “Services”) as the Company may from time to time reasonably request the Services shall include, without limitation, the following:

Ø Assistance with investor presentations such as, but not limited to, PowerPoint slide presentations, broker/dealer fact sheets, financial projections and budgets;

Ø Sponsorship to capital conferences;

Ø Identification and evaluation of financing transactions;

Ø Identification and evaluation of acquisition and/or merger candidates;

Ø Introductions to broker/dealers, research analysts, and investment companies that Legend believes could be helpful to the Company, including expanded introductions to broker/dealers, analysts and potential investors in regions outside of the New York area;

Ø Arranging meetings between CytRx management and broker/dealers, research analysts, and investment companies in coordination with the Company’s management’s travel schedule;

Ø Providing the CEO of the Company a detailed report, no less frequently than once every two months, substantiating Legend’s activities conducted pursuant to this Agreement during the preceding period.

4. The term of this Agreement shall be twenty-four (24) months from the Effective Date of this Agreement; provided that the Company may, in its sole discretion, extend the Term for up to an additional six (6) months by providing notice of such extension to Legend at any time prior to the expiration of this Agreement (such period, as it may be extended pursuant to this sentence, the "Term"), and the additional compensation owed to Legend during any such extension shall be the Monthly Advisory Fee described hi Section 5. Except as set forth in this paragraph, the Agreement may not be terminated by the Parties other than as a result of a material breach of any provision of this agreement that is not cured within ten (10) days following notification thereof by the non-breaching party.

5. In consideration for the services described herein, the Company shall pay to Legend a monthly advisory fee of thirty thousand dollars ($30,000.00) per month (the "Monthly Advisory Fee"). The first month advisory fee shall be paid to Legend on the Effective Date and thereafter no later than the fifteenth (15th) day of each monthly anniversary of the Effective Date during the Term of this Agreement; provided that no fee shall be payable if Legend is in default of its obligations to deliver the report to the Company’s CEO described in Section 3 above unless and until such report is delivered. The Monthly Advisory Fee shall be earned and payable each month and may not be deferred by the Company unless the Company submits a written request to the Legend and Legend approves such request in writing. The Monthly Advisory Fee shall be mailed to Legend at the following address:

Legend Securities, Inc

Attn: Salvatore Caruso

45 Broadway 32nd Fl.

 New York, NY 10006

Phone: 212-344-5747 ext 3031

Fax: 212-898-1224

6. Simultaneously with the execution of this Agreement, the Company shall issue and deliver to Legend a common stock warrant (the “WARRANT”) for the purchase of five hundred thousand (500,000) shares of the Company’s common stock with an exercise price equal to the closing price on the Effective Date. Notwithstanding the foregoing, the Company shall vest completely and in favor of the Legend as follows:

Date                                                                                                Number of Warrants

The Effective Date                                                                                               100,000

Each Six-Month Anniversary of The Effective Date until fully vested100,000

7. The Warrant, upon issuance, shall be fully paid, non-assessable, and free of any restrictions on transfer, but for those restrictions that are the result of State or Federal securities laws. The Warrant shall be issued to Legend in the form of a warrant agreement (the “Warrant Agreement”), which shall be in a  form and content reasonably satisfactory to Legend and its counsel and the Company and its counsel. The Warrant Agreement shall provide for, among other provisions, the above terms and the following: (1) The Warrant shall expire five years after the date that the Warrant Agreement is issued; (2) The Warrant Agreement shall have customary anti-dilution provisions for stock dividends, splits, mergers, and sale of substantially all assets of the Company; (3) Legend may exercise the Warrant at any time after signing the Warrant Agreement to the extent vested as described in Section 6; (4) The Warrants shall contain a “Cashless Exercise” provision that may be utilized 180 days after issuance if there is not an effective Registration Statement covering the underlying common shares; (5) The Company shall reserve , and at all times have available, a sufficient number of shares of its common stock to be issued upon the exercise of the Warrant; and (6) The Company shall grant unlimited "piggy back" registration rights, at the Company's expense, to include the shares of the underlying common stock in any registration statement filed by the Company under the Securities Act of 1933 relating to an underwriting of the sale of shares of common stock or other security of the Company, subject to existing contractual obligations of the Company and other customary limitations.

8. The Company will promptly notify Legend in writing upon the filing of any registration statement or other periodic reporting documents filed pursuant to the rules and regulations of the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended.

9. The Company recognizes that Legend now renders and may continue to render financial consulting, management, investment banking and other services to other companies that may or may not conduct business and activities similar to those of the Company. Legend shall be free to render such advice and other services and the Company hereby consents thereto. Legend shall not be required to devote its full time and attention to the performance of its duties under this Agreement, but shall devote sufficient time and attention as is reasonably necessary to fulfill its obligation hereunder.

10. During the Term of this Agreement the Company covenants, promises and agrees that the Company shall immediately notify Legend if it is the subject of any material investigation or material litigation.

11. This Agreement shall be governed by and construed under the laws of the State of New York without regard to principals of conflicts of laws provisions. In the event of any dispute between the Company and Legend arising under or pursuant to the terms of this Agreement, or any matters arising under the terms of this Agreement, the same shall be settled only by arbitration through FINRA Dispute Resolution in County of New York, New York City, State of New York, in accordance with the Code of Arbitration Procedure published by FINRA Dispute Resolution. The determination of the arbitrators shall be final and binding upon the Company and Legend and may be enforced in any court of appropriate jurisdiction. This Agreement shall be construed by and governed exclusively under the laws of the State of New York, without regard to its conflicts of law provisions. The venue shall be in County of New York, NY.

12. The Company shall reimburse Legend for all approved out of pocket expenses, including without limitation acceptable travel and lodging, printing, legal, and mailing cost that Legend may incur in performance of the Services under this Agreement, provided Legend receives the Company's prior approval for any and all out of pocket expenses above five hundred dollars.

13. [A]  The Company shall indemnify and hold harmless Legend and its directors, officers, employees, agents, attorneys and assigns from and against any and all losses, claims, costs, damages or liabilities (including the reasonable fees and expenses of legal counsel) to which any of them may become subject in connection with the investigation, defense or settlement of any actions or claims: (i)caused by any untrue statement or alleged untrue statement of any material fact contained in any Information provided by the Company or the omission or alleged omission to state a material fact required to be stated in any such Information or necessary to make the statements in any Information not misleading, provided such Information was used by Legend in rendering any Service hereunder; (ii) arising in any manner out of or in connection with the rendering of Services by Legend hereunder; or (iii) otherwise in connection with this Agreement; provided, however, that the Company will not be liable in any such case if and to the extent that any such loss, claim, cost, damage or liability arises out of any breach of this Agreement by Legend, or any misrepresentation or alleged misrepresentation of the material facts provided to Legend by the Company or arising from acts of gross negligence or malfeasance by Legend or any breach by Legend of this Agreement.

[B]           Legend shall indemnify and hold harmless the Company and its directors, officers, employees, agents, attorneys and assigns from and against any and all losses, claims, costs, damages or liabilities (including the reasonable fees and expenses of legal counsel) to which any of them may become subject in connection with the investigation, defense or settlement of any actions or claims: (i) caused by any untrue statement or alleged untrue statement of any material fact contained in any information provided by Legend other than Information provided to Legend by the Company ("Legend Information") or the omission or alleged omission to state a material fact required to be stated in any such Legend Information or necessary to make the statements in any Legend Information not misleading; (ii) arising in any manner out of or in connection with the rendering of Services by Legend hereunder; or (iii) otherwise in connection with this Agreement; provided, however, that Legend will not be liable in any such case if and to the extent that any such loss, claim, cost, damage or liability arises out of any breach of this Agreement by the Company or arising from acts of gross negligence or malfeasance by the Company or any breach by the Company of this Agreement

[C]           Promptly after receipt of notice of the commencement of any action, the party against whom an action is brought (the "Indemnified Party") shall, if a claim is also being made against the other party (the "Indemnifying Party") for indemnification pursuant to this Agreement, notify the Indemnifying Party in writing of such action; provided that, the Indemnifying Party shall be relieved from any obligation to indemnify the Indemnified Party pursuant to this Agreement to the extent that any delay by the Indemnified Party to provide notice to the Indemnifying Party pursuant to this Section impairs or prejudices the Indemnifying Party's ability to assume and defend any such action. In case any such action shall be brought against the Indemnified Party it shall notify the Indemnifying Party of the commencement of such action, and the Indemnifying Party shall be entitled to participate in and, to the extent it shall wish, to assume and undertake the defense thereof with counsel reasonably satisfactory to the Indemnified Party, and, after notice from the Indemnifying Party to the Indemnified Party of its election so to assume and undertake the defense of such action, the Indemnifying Party shall not be liable to the Indemnified Party under this paragraph 13 for any legal expenses subsequently incurred by the Indemnified Party in connection with the defense of such action; if the Indemnified Party retains its own counsel, then Indemnified Party shall pay all fees, costs and expenses of such counsel, provided, however, that, if the defendants in any such action include both the Indemnified Party and the Indemnifying Party and the Indemnified Party shall have reasonably concluded that there may be reasonable defenses available to it which are different from or additional to those available to the Indemnifying Party or if the interests of the Indemnified Party reasonably may be deemed to conflict with the interests of the Indemnifying Party, the Indemnifying Party and the Indemnified Party shall have the right to select one separate counsel and to assume such legal defenses and otherwise to participate in the defense of such action, with the reasonable expenses and fees of such separate counsel and other expenses related to such participation to be reimbursed by the Indemnifying Party as incurred.

14. The Company acknowledges that Legend has made no guarantees that its performance hereunder will achieve any particular result with respect to the Company's business, stock price, trading volume, market capitalization or otherwise.

15. All notices hereunder shall be in writing and shall be validly given, made or served if in writing and delivered in person or when received by facsimile transmission, or five days after being sent first class certified or registered mail, postage prepaid, or one day after being sent by nationally recognized overnight carrier to the party for whom intended at the address set forth after each Parties signatures.

16. If any clause or provision of this Agreement is illegal, invalid or unenforceable under applicable present or future Laws effective during the Term, the remainder of this Agreement shall not be affected. In lieu of each clause or provision of this Agreement that is illegal, invalid or unenforceable, there shall be added as a part of this Agreement a clause or provision as nearly identical as may be possible and as may be legal, valid and enforceable. In the event any clause or provision of this Agreement is illegal, invalid or unenforceable as aforesaid and the effect of such illegality, invalidity or unenforceability is that either party no longer has the substantial benefit of its bargain under this Agreement and a clause or provision as nearly identical as may be possible cannot be added, then, in such event, such party may in its discretion cancel and terminate this entire Agreement provided such party exercises such right within a reasonable time after such occurrence.

17. The Parties agree and acknowledge that they have jointly participated in the negotiation and drafting of this Agreement and that this Agreement has been fully reviewed and negotiated by the Parties and their respective counsel. In the event of an ambiguity or question of intent or interpretation arises, this Agreement shall be construed as if drafted jointly by the Parties and no presumptions or burdens of proof shall arise favoring any party by virtue of the authorship of any of the provisions of this Agreement.

18. This Agreement may not be modified, amended, supplemented, canceled or discharged, except by written instrument executed by all Parties. No failure to exercise, and no delay in exercising, any right, power or privilege under this Agreement shall operate as a waiver, nor shall any single or partial exercise of any right, power or privilege hereunder preclude the exercise of any other right, power or privilege. No waiver of any breach of any provision shall be deemed to be a waiver of any preceding or succeeding breach of the same or any other provision, nor shall any waiver be implied from any course of dealing between the Parties. To be effective, all waivers must be in writing, signed by both Parties. The rights and remedies of the Parties under this Agreement are in addition to all other rights and remedies, at law or equity, that they may have against each other except as may be specifically limited herein.

19. This Agreement contains the entire understanding of the Parties in respect of its subject matter and supersedes all prior agreements and understandings (oral or written) between or among the Parties with respect to such subject matter. The Parties agree that prior drafts of this Agreement shall not be deemed to provide any evidence as to the meaning of any provision hereof or the intent of the Parties with respect thereto. Any amendment or modification to the Agreement shall be by written instrument only and must be executed by a representative, with complete authority, from the Company and Legend.

20. This Agreement may be executed in any number of counterparts, each of which shall bean original but all of which together shall constitute one and the same instrument. A telecopy signature of any party shall be considered to have the same binding legal effect as an original signature.

21. In the event that any dispute among the Parties to this Agreement should result in litigation, the substantially prevailing party in such dispute shall be entitled to recover from the losing party all fees, costs and expenses of enforcing any right of such substantially prevailing party under or with respect to this Agreement, including without limitation, such reasonable fees and expenses of attorneys and accountants, which shall include, without limitation, all fees, costs and expenses of appeals and collection.

[REMAINDER OF THIS PAGE LEFT INTENTIONALLY BLANK]

If the foregoing is in accordance with your understanding, kindly confirm your acceptance and agreement by signing and returning the enclosed duplicate of this Agreement that will thereupon constitute and agreement between us.

Very truly yours,

/s/ SALVATORE CARUSO

Legend Securities, Inc.

Accepted and approved this 5th day of August, 2013

By: /s/ STEVEN KRIEGSMAN

 President and CEO

 CytRx Corporation

EX-31.1

Exhibit 31.1

CERTIFICATIONS

I, Steven A. Kriegsman, Chief Executive Officer of CytRx Corporation, certify that:

1. I have reviewed this quarterly report on Form 10-Q of CytRx Corporation;

2. Based on my knowledge, this quarterly report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the periods covered by this quarterly report;

3. Based on my knowledge, the financial statements, and other financial information included in this quarterly report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this quarterly report;

4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

(a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its  subsidiaries, is made known to us by others within those entities, particularly during the period in which this quarterly report is being prepared;

(b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

(c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the periods covered by this report based on such evaluation; and

(d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

(a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

(b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: August 6, 2013	By:	/s/ STEVEN A. KRIEGSMAN
		Steven A. Kriegsman
		Chief Executive Officer

EX-31.2

Exhibit 31.2

CERTIFICATIONS

I, John Y. Caloz, Chief Financial Officer of CytRx Corporation, certify that:

1. I have reviewed this quarterly report on Form 10-Q of CytRx Corporation;

2. Based on my knowledge, this quarterly report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the periods covered by this quarterly report;

3. Based on my knowledge, the financial statements, and other financial information included in this quarterly report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this quarterly report;

4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

(a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its  subsidiaries, is made known to us by others within those entities, particularly during the period in which this quarterly report is being prepared;

(b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

(c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the periods covered by this report based on such evaluation; and

(d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

(a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

(b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: August 6, 2013	By:	/s/ JOHN Y. CALOZ
		John Y. Caloz
		Chief Financial Officer

EX-32.1

Exhibit 32.1

Certification of Chief Executive Officer

Pursuant to 18 U.S.C. 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, the undersigned officer of CytRx Corporation (the “Company”) hereby certifies based on his knowledge that:

(i) the accompanying Quarterly Report on Form 10-Q of the Company for the period ended June 30, 2013 as filed with the Securities and Exchange Commission on the date hereof (the “Report”) fully complies with the requirements of Section 13(a) or Section 15(d), as applicable, of the Securities Exchange Act of 1934, as amended; and

(ii) the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company as of and for the periods covered in the Report.

Date: August 6, 2013	By:	/s/ STEVEN A. KRIEGSMAN
		Steven A. Kriegsman
		Chief Executive Officer

A signed original of this written statement required by Section 906 of the Sarbanes-Oxley Act of 2002 (Section 906), or other document authenticating, acknowledging, or otherwise adopting the signature that appears in typed form within the electronic version of this written statement required by Section 906, has been provided to CytRx Corporation and will be retained by CytRx Corporation and furnished to the Securities and Exchange Commission or its staff upon request.

The foregoing certification is being furnished to the Securities and Exchange Commission as an Exhibit to the Form 10-Q and shall not be considered filed as part of the Form 10-Q.

EX-32.2

Exhibit 32.2

Certification of Chief Financial Officer

Pursuant to 18 U.S.C. 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, the undersigned officer of CytRx Corporation (the “Company”) hereby certifies based on his knowledge that:

(i) the accompanying Quarterly Report on Form 10-Q of the Company for the period ended June 30, 2013 as filed with the Securities and Exchange Commission on the date hereof (the “Report”) fully complies with the requirements of Section 13(a) or Section 15(d), as applicable, of the Securities Exchange Act of 1934, as amended; and

(ii) the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company as of and for the periods covered in the Report.

Date: August 6, 2013	By:	/s/ JOHN Y. CALOZ
		John Y. Caloz
		Chief Financial Officer

A signed original of this written statement required by Section 906 of the Sarbanes-Oxley Act of 2002 (Section 906), or other document authenticating, acknowledging, or otherwise adopting the signature that appears in typed form within the electronic version of this written statement required by Section 906, has been provided to CytRx Corporation and will be retained by CytRx Corporation and furnished to the Securities and Exchange Commission or its staff upon request.

The foregoing certification is being furnished to the Securities and Exchange Commission as an Exhibit to the Form 10-Q and shall not be considered filed as part of the Form 10-Q.

XML

Stock Based Compensation (Tables)

6 Months Ended

Jun. 30, 2013

Stock Based Compensation [Abstract]

Schedule of total stock-based compensation expense from stock options and warrants

The following table sets forth the total stock-based compensation expense resulting from stock options and warrants included in the Company’s unaudited interim statements of operations:

	Three Months Ended June 30,				Six Months Ended June 30,
	2013		2012		2013		2012
Research and development — employee	$	53,583	$	98,242	$	103,755	$	193,366
General and administrative — employee		202,589		263,007		387,229		437,079
Total employee stock-based compensation	$	256,172	$	361,249	$	490,984	$	630,445
Research and development — non-employee	$	—	$	—	$	—	$	—
General and administrative — non-employee		152,074		176,074		179,286		228,492
Total non-employee stock-based compensation	$	152,074	$	176,074	$	179,286	$	228,492

Schedule of share-based payment award, fair value of the stock options granted , assumptions

During the six-month period ended June 30, 2013, the Company issued stock options to purchase 117,176 shares of its common stock. The fair value of the stock options granted in the current six-month period was estimated using the Black-Scholes option-pricing model, based on the following assumptions:

	Six Months Ended June 30, 2013			Six Months Ended June 30, 2012
Risk-free interest rate		1.11	%		1.54	%
Expected volatility		85.2% - 85.8	%		89.7% - 97.7	%
Expected lives (years)		6			6 - 10
Expected dividend yield		0.00	%		0.00	%

Schedule of share-based compensation, stock options, activity

As of June 30, 2013, there remained approximately $1.3 million of unrecognized compensation expense related to unvested stock options granted to current and former employees, directors and consultants, to be recognized as expense over a weighted-average period of 1.13 years. Presented below is the Company’s stock option activity:

	Six Months Ended June 30, 2013
	Number of Options (Employees)			Number of Options (Non-Employees)		Total Number of Options			Weighted-Average Exercise Price
Outstanding at January 1, 2013		3,240,850			142,143		3,382,993		$	4.17
Granted		92,176			25,000		117,176		$	2.52
Exercised		(476	)		—		(476	)	$	1.96
Forfeited or expired		(103,716	)		—		(103,716	)	$	3.08
Outstanding at June 30, 2013		3,228,834			167,143		3,395,977		$	4.15
Options exercisable at June 30, 2013		2,159,480			149,881		2,309,361		$	5.10

Schedule of unvested stock options activity

A summary of the unvested stock options as of June 30, 2013, and changes during the six-month period then ended, is presented below:

	Number of Options (Employees)			Number of Options (Non-Employees)			Total Number of Options			Weighted-Average Grant Date Fair Value per Share
Non-vested at January 1, 2013		1,322,389			8,929			1,331,318		$	1.69
Granted		92,176			25,000			117,176		$	1.80
Forfeited or expired		(103,716	)		—			(103,716	)	$	2.32
Vested		(241,495	)		(16,667	)		(258,162	)	$	3.68
Non-vested at June 30, 2013		1,069,354			17,262			1,086,616		$	1.67

Schedule of share-based compensation, summarizes significant ranges of outstanding stock options

The following table summarizes significant ranges of outstanding stock options under the Company’s plans at June 30, 2013:

Range of Exercise Prices		Number of Options		Weighted-Average Remaining Contractual Life (years)		Weighted-Average Exercise Price		Number of Options Exercisable		Weighted-Average Contractual Life		Weighted-Average Exercise Price
$	1.83 - 3.00		2,143,069		8.99	$	1.99		1,100,587		8.99	$	2.04
$	3.01 –7.00		178,512		4.77	$	5.24		176,036		4.77	$	5.26
$	7.01 –8.50		942,110		4.63	$	7.66		900,452		4.63	$	7.68
$	8.51 – 32.55		132,286		1.33	$	12.75		132,286		1.33	$	12.75
			3,395,977		7.26	$	4.15		2,309,361		7.26	$	5.10

XML

CONDENSED STATEMENTS OF OPERATIONS (Unaudited) (USD $)	3 Months Ended		6 Months Ended
	Jun. 30, 2013	Jun. 30, 2012	Jun. 30, 2013	Jun. 30, 2012
Revenue:
License revenue	$ 200,000	$ 0	$ 200,000	$ 0
Expenses:
Research and development	4,626,244	2,686,465	7,815,003	7,087,980
General and administrative	1,970,930	2,091,856	3,788,255	4,006,572
Total Expenses	6,597,174	4,778,321	11,603,258	11,094,552
Loss before other income (loss)	(6,397,174)	(4,778,321)	(11,403,258)	(11,094,552)
Other income (loss):
Interest income	35,564	27,547	75,822	63,005
Other income, net	4,761	16,491	201,698	50,551
Gain (loss) on warrant derivative liability	2,933,707	(8,528,192)	838,487	(12,416,358)
Net loss	$ (3,423,142)	$ (13,262,475)	$ (10,287,251)	$ (23,397,354)
Basic and diluted net loss per share (in dollars per share)	$ (0.11)	$ (0.63)	$ (0.34)	$ (1.10)
Basic and diluted weighted average shares outstanding (in shares)	30,418,435	21,204,499	30,417,906	21,203,754

XML

Basic and Diluted Net Loss Per Common Share

6 Months Ended

Jun. 30, 2013

Basic and Diluted Net Loss Per Common Share [Abstract]

Basic and Diluted Net Loss Per Common Share

5. Basic and Diluted Net Loss Per Common Share

Basic and diluted net loss per common share is computed based on the weighted-average number of common shares outstanding. Common share equivalents (which consist of options, warrants and restricted stock) are excluded from the computation of diluted net income (loss) per common share where the effect would be anti-dilutive. Common share equivalents that could potentially dilute net income (loss) per share in the future, and which were excluded from the computation of diluted loss per share, totaled 11.2 million shares for the three-month and six-month periods ended June 30, 2013, and 9.6 million shares for the three-month and six-month periods ended June 30, 2012.

XML

Stock Based Compensation (Details) (USD $)	3 Months Ended		6 Months Ended
	Jun. 30, 2013	Jun. 30, 2012	Jun. 30, 2013	Jun. 30, 2012
Share-based compensation arrangement by share-based payment award, fair value assumptions and methodology [Abstract]
Unrecognized compensation cost, recognized as expense over a weighted-average period			1 year 1 month 17 days
Employees [Member]
Share-based compensation arrangement by share-based payment award, fair value assumptions and methodology [Abstract]
Estimated annualized forfeiture rate (in hundredths)			12.00%	14.00%
Employees and Directors [Member]
Share-based compensation arrangement by share-based payment award, fair value assumptions and methodology [Abstract]
Unrecognized compensation expense related to unvested stock options, granted	$ 1,300,000		$ 1,300,000
Senior management [Member]
Share-based compensation arrangement by share-based payment award, fair value assumptions and methodology [Abstract]
Estimated annualized forfeiture rate (in hundredths)			3.00%	2.00%
Directors and nonemployees [Member]
Share-based compensation arrangement by share-based payment award, fair value assumptions and methodology [Abstract]
Estimated annualized forfeiture rate (in hundredths)			0.00%	0.00%
Stock Options [Member]
Share-based compensation arrangement by share-based payment award, fair value assumptions and methodology [Abstract]
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Method Used			Black-Scholes option-pricing model
Risk-free interest rate (in hundredths)			1.11%	1.54%
Expected volatility, Minimum (in hundredths)			85.20%	89.70%
Expected volatility, Maximum (in hundredths)			85.80%	97.70%
Expected lives			6 years
Expected dividend yield (in hundredths)			0.00%	0.00%
Number of Options (Employees and Non-Employees) [Abstract]
Outstanding at beginning of period (in shares)			3,382,993
Granted (in shares)			117,176
Exercised (in shares)			(476)
Forfeited or expired (in shares)			(103,716)
Outstanding at end of period (in shares)	3,395,977		3,395,977
Options exercisable at end of period (in shares)	2,309,361		2,309,361
Weighted-Average Exercise Price Options [Abstract]
Outstanding at beginning of period (in dollars per share)			$ 4.17
Granted (in dollars per share)			$ 2.52
Exercised (in dollars per share)			$ 1.96
Forfeited or expired (in dollars per share)			$ 3.08
Outstanding at end of period (in dollars per share)	$ 4.15		$ 4.15
Options exercisable at end of period (in dollars per share)	$ 5.10		$ 5.10
Number of Unvested Stock Options (Employees and Non-Employees) [Abstract]
Non-vested at beginning of period (in shares)			1,331,318
Granted, unvested stock options (in shares)			117,176
Forfeited or expired, unvested stock options (in shares)			(103,716)
Vested (in shares)			(258,162)
Non-vested at end of period (in shares)	1,086,616		1,086,616
Weighted average grant date fair value per share [Abstract]
Non-vested at beginning of period (in dollars per share)			$ 1.69
Granted, unvested stock options (in dollars per share)			$ 1.80
Forfeited or expired, unvested stock options (in dollars per share)			$ 2.32
Vested (in dollars per share)			$ 3.68
Non-vested at end of period (in dollars per share)	$ 1.67		$ 1.67
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Share-based compensation arrangement by share-based payment award, shares issued in period (in shares)			117,176
Share based compensation, shares authorized under significant ranges of outstanding stock option plans in period [Abstract]
Number of Options (in shares)	3,395,977		3,395,977
Weighted-Average Remaining Contractual Life			7 years 3 months 4 days
Weighted-Average Exercise Price (in dollars per share)	$ 4.15		$ 4.15
Number of Options Exercisable (in shares)	2,309,361		2,309,361
Weighted-Average Contractual Life			7 years 3 months 4 days
Weighted-Average Exercise Price, Options Exercisable (in dollars per share)	$ 5.10		$ 5.10
The aggregate intrinsic value of outstanding options	2,700,000		2,700,000
Closing price of the common stock (in dollars per share)	$ 2.00		$ 2.00
Stock Options [Member] | Range $ 1.83 - 3.00 [Member]
Share based compensation, shares authorized under significant ranges of outstanding stock option plans in period [Abstract]
Range of Exercise Prices, Lower Range (in dollars per share)			$ 1.83
Range of Exercise Prices, Upper Range (in dollars per share)			$ 3.00
Number of Options (in shares)	2,143,069		2,143,069
Weighted-Average Remaining Contractual Life			8 years 11 months 26 days
Weighted-Average Exercise Price (in dollars per share)	$ 1.99		$ 1.99
Number of Options Exercisable (in shares)	1,100,587		1,100,587
Weighted-Average Contractual Life			8 years 11 months 26 days
Weighted-Average Exercise Price, Options Exercisable (in dollars per share)	$ 2.04		$ 2.04
Stock Options [Member] | Range $ 3.01 - 7.00 [Member]
Share based compensation, shares authorized under significant ranges of outstanding stock option plans in period [Abstract]
Range of Exercise Prices, Lower Range (in dollars per share)			$ 3.01
Range of Exercise Prices, Upper Range (in dollars per share)			$ 7.00
Number of Options (in shares)	178,512		178,512
Weighted-Average Remaining Contractual Life			4 years 9 months 7 days
Weighted-Average Exercise Price (in dollars per share)	$ 5.24		$ 5.24
Number of Options Exercisable (in shares)	176,036		176,036
Weighted-Average Contractual Life			4 years 9 months 7 days
Weighted-Average Exercise Price, Options Exercisable (in dollars per share)	$ 5.26		$ 5.26
Stock Options [Member] | Range $ 7.01 - 8.50 [Member]
Share based compensation, shares authorized under significant ranges of outstanding stock option plans in period [Abstract]
Range of Exercise Prices, Lower Range (in dollars per share)			$ 7.01
Range of Exercise Prices, Upper Range (in dollars per share)			$ 8.50
Number of Options (in shares)	942,110		942,110
Weighted-Average Remaining Contractual Life			4 years 7 months 17 days
Weighted-Average Exercise Price (in dollars per share)	$ 7.66		$ 7.66
Number of Options Exercisable (in shares)	900,452		900,452
Weighted-Average Contractual Life			4 years 7 months 17 days
Weighted-Average Exercise Price, Options Exercisable (in dollars per share)	$ 7.68		$ 7.68
Stock Options [Member] | Range $ 8.51 - 32.55 [Member]
Share based compensation, shares authorized under significant ranges of outstanding stock option plans in period [Abstract]
Range of Exercise Prices, Lower Range (in dollars per share)			$ 8.51
Range of Exercise Prices, Upper Range (in dollars per share)			$ 32.55
Number of Options (in shares)	132,286		132,286
Weighted-Average Remaining Contractual Life			1 year 3 months 29 days
Weighted-Average Exercise Price (in dollars per share)	$ 12.75		$ 12.75
Number of Options Exercisable (in shares)	132,286		132,286
Weighted-Average Contractual Life			1 year 3 months 29 days
Weighted-Average Exercise Price, Options Exercisable (in dollars per share)	$ 12.75		$ 12.75
Stock Options [Member] | Minimum [Member]
Share-based compensation arrangement by share-based payment award, fair value assumptions and methodology [Abstract]
Expected lives				6 years
Stock Options [Member] | Maximum [Member]
Share-based compensation arrangement by share-based payment award, fair value assumptions and methodology [Abstract]
Expected lives			10 years	10 years
Stock Options [Member] | Employees [Member]
Number of Options (Employees and Non-Employees) [Abstract]
Outstanding at beginning of period (in shares)			3,240,850
Granted (in shares)			92,176
Exercised (in shares)			(476)
Forfeited or expired (in shares)			(103,716)
Outstanding at end of period (in shares)	3,228,834		3,228,834
Options exercisable at end of period (in shares)	2,159,480		2,159,480
Number of Unvested Stock Options (Employees and Non-Employees) [Abstract]
Non-vested at beginning of period (in shares)			1,322,389
Granted, unvested stock options (in shares)			92,176
Forfeited or expired, unvested stock options (in shares)			(103,716)
Vested (in shares)			(241,495)
Non-vested at end of period (in shares)	1,069,356		1,069,356
Stock Options [Member] | Non employees [Member]
Number of Options (Employees and Non-Employees) [Abstract]
Outstanding at beginning of period (in shares)			142,143
Granted (in shares)			25,000
Exercised (in shares)			0
Forfeited or expired (in shares)			0
Outstanding at end of period (in shares)	167,143		167,143
Options exercisable at end of period (in shares)	149,881		149,881
Number of Unvested Stock Options (Employees and Non-Employees) [Abstract]
Non-vested at beginning of period (in shares)			8,929
Granted, unvested stock options (in shares)			25,000
Forfeited or expired, unvested stock options (in shares)			0
Vested (in shares)			(16,667)
Non-vested at end of period (in shares)	17,262		17,262
Stock Options And Warrants [Member] | Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	256,172	361,249	490,984	630,445
Stock Options And Warrants [Member] | Non-Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	152,074	176,074	179,286	228,492
Stock Options And Warrants [Member] | Research and Development Expense [Member] | Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	53,583	98,242	103,755	193,366
Stock Options And Warrants [Member] | Research and Development Expense [Member] | Non-Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	0	0	0	0
Stock Options And Warrants [Member] | General and Administrative Expense [Member] | Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	202,589	263,007	387,229	437,079
Stock Options And Warrants [Member] | General and Administrative Expense [Member] | Non-Employees [Member]
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	152,074	176,074	179,286	228,492
Restricted Stock [Member]
Number of Options (Employees and Non-Employees) [Abstract]
Outstanding at end of period (in shares)	100,000		100,000
Number of Unvested Stock Options (Employees and Non-Employees) [Abstract]
Granted, unvested stock options (in shares)			100,000
Total stock-based compensation expense resulting from stock options and warrants [Abstract]
Allocated employee and non-employee stock-based compensation expense, Total	46,495	0	92,478	0
2000 Long Term Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Common stock reserved for future issuance (in shares)	1,400,000		1,400,000
Share-based compensation, shares subject to stock options (in shares)	1,000,000		1,000,000
Expiration date			Aug. 06, 2010
Share-based compensation, shares available for future grant (in shares)	0		0
2008 Stock Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Common stock reserved for future issuance (in shares)	5,000,000		5,000,000
Share-based compensation, shares subject to stock options (in shares)	2,400,000		2,400,000
Share-based compensation, shares available for future grant (in shares)	2,600,000		2,600,000
2008 Stock Incentive Plan [Member] | Restricted Stock [Member]
Weighted average grant date fair value per share [Abstract]
Expected to vest (in shares)	50,000		50,000
Expected to vest over subsequent period (in shares)	50,000		50,000
Value of restricted shares issued	$ 186,900		$ 186,900

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Fair Value Measurements (Tables)

6 Months Ended

Jun. 30, 2013

Fair Value Measurements [Abstract]

Fair value measurements by level for assets and liabilities measured at fair value on a recurring basis

The following table summarizes fair value measurements by level at June 30, 2013 for assets and liabilities measured at fair value on a recurring basis:

(In thousands)	Level I		Level II		Level III		Total
Cash equivalents	$	10,384	$	—	$	—	$	10,384
Short-term investments		17,000		—		—		17,000
Warrant liability		—		—		3,134		3,134

The following table summarizes fair value measurements by level at December 31, 2012 for assets and liabilities measured at fair value on a recurring basis:

(In thousands)	Level I		Level II		Level III		Total
Cash equivalents	$	13,188	$	—	$	—	$	13,188
Short-term investments		24,000		—		—		24,000
Warrant liabilities		—		—		3,972		3,972

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Liquidity and Capital Resources (Details) (USD $)	6 Months Ended
	Jun. 30, 2013	Dec. 31, 2012	Jun. 30, 2012	Dec. 31, 2011
Estimated projected expenditure [Line Items]
Cash and cash equivalents	$ 10,980,486	$ 14,344,088	$ 11,859,009	$ 17,988,590
Marketable securities	17,000,000	24,000,000
Currently projected expenditures for clinical programs	20,700,000
Aldoxorubicin [Member]
Estimated projected expenditure [Line Items]
Currently projected expenditures for clinical programs	8,100,000
Tamibarotene and Bafetinib [Member]
Estimated projected expenditure [Line Items]
Currently projected expenditures for clinical programs	1,200,000
General Operation [Member]
Estimated projected expenditure [Line Items]
Currently projected expenditures for clinical programs	4,700,000
Other General and Administrative Expenses [Member]
Estimated projected expenditure [Line Items]
Currently projected expenditures for clinical programs	$ 6,700,000

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Fair Value Measurements (Details) (Recurring [Member], USD $) In Thousands, unless otherwise specified	Jun. 30, 2013	Dec. 31, 2012
Fair value measurements by level for assets and liabilities measured at fair value on a recurring basis [Abstract]
Cash equivalents	$ 10,384	$ 13,188
Short-term investments	17,000	24,000
Warrant liability	3,134	3,972
Level I [Member]
Fair value measurements by level for assets and liabilities measured at fair value on a recurring basis [Abstract]
Cash equivalents	10,384	13,188
Short-term investments	17,000	24,000
Warrant liability	0	0
Level II [Member]
Fair value measurements by level for assets and liabilities measured at fair value on a recurring basis [Abstract]
Cash equivalents	0	0
Short-term investments	0	0
Warrant liability	0	0
Level III [Member]
Fair value measurements by level for assets and liabilities measured at fair value on a recurring basis [Abstract]
Cash equivalents	0	0
Short-term investments	0	0
Warrant liability	$ 3,134	$ 3,972

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Description of Company and Basis of Presentation

6 Months Ended

Jun. 30, 2013

Description of Company and Basis of Presentation [Abstract]

Description of Company and Basis of Presentation

1. Description of Company and Basis of Presentation

CytRx Corporation (“CytRx” or the “Company”) is a biopharmaceutical research and development company specializing in oncology. The CytRx oncology pipeline is focused on the clinical development of aldoxorubicin (formerly known as INNO-206), its improved version of the widely used chemotherapeutic agent doxorubicin. CytRx has reached targeted enrollment in an international Phase 2b clinical trial with aldoxorubicin as a treatment for soft tissue sarcomas and completed a Phase 1b/2 clinical trial primarily in the same indication and a Phase 1b study of aldoxorubicin in combination with doxorubicin in patients with advanced solid tumors. CytRx also is conducting a Phase 1b pharmacokinetics clinical trial of aldoxorubicin in patients with metastatic solid tumors. The Company is initiating a Phase 3 pivotal trial under a special protocol assessment (SPA) with aldoxorubicin as a therapy for patients with soft tissue sarcomas whose tumors have progressed following treatment with chemotherapy. CytRx may seek to expand its pipeline of oncology candidates based on a novel linker platform technology used in aldoxorubicin that can be utilized with multiple chemotherapeutic agents and may allow for greater concentration of the agents at tumor sites. The Company also has rights to two additional drug candidates, tamibarotene and bafetinib. The Company completed its evaluation of bafetinib in the ENABLE Phase 2 clinical trial in high-risk B-cell chronic lymphocytic leukemia (B-CLL), and plans to seek a partner for further development. CytRx is evaluating plans for further development of tamibarotene.

The accompanying condensed financial statements at June 30, 2013 and for the three-month and six-month periods ended June 30, 2013 and 2012 are unaudited, but include all adjustments, consisting of normal recurring entries, that management believes to be necessary for a fair presentation of the periods presented. Prior period figures have been reclassified, wherever necessary, to conform to current presentation. Interim results are not necessarily indicative of results for a full year. Balance sheet amounts as of December 31, 2012 have been derived from the Company’s audited financial statements as of that date.

The financial statements included herein have been prepared by the Company pursuant to the rules and regulations of the Securities and Exchange Commission (“SEC”). Certain information and footnote disclosures normally included in financial statements prepared in accordance with accounting principles generally accepted in the United States of America have been condensed or omitted pursuant to such rules and regulations. The financial statements should be read in conjunction with the Company’s audited financial statements contained in its Annual Report on Form 10-K for the year ended December 31, 2012. The Company’s operating results will fluctuate for the foreseeable future. Therefore, period-to-period comparisons should not be relied upon as predictive of the results in future periods.

Effective May 15, 2012, the Company completed a 1-for-7 reverse stock split of the Company’s outstanding shares of common stock; no change was made to the per-share par value per share of the common stock or to the number of shares of authorized common stock. All share and per share amounts in the accompanying consolidated financial statements have been adjusted to reflect the reverse stock split as if it had occurred at the beginning of the earliest period presented.

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Short-term Investments

6 Months Ended

Jun. 30, 2013

Short-term Investments [Abstract]

Short-term Investments

3.  Short-term Investments

The Company held $17.0 million of short-term investments at June 30, 2013. The Company has classified these investments as available for sale. These investments are federally insured certificates of deposit and have a maturity date of October 31, 2013.

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Warrant Liabilities

6 Months Ended

Jun. 30, 2013

Warrant Liabilities [Abstract]

Warrant Liabilities

6. Warrant Liabilities

Liabilities measured at market value on a recurring basis include warrant liabilities resulting from the Company’s past equity financings, including the underwritten public offering that closed on August 1, 2011. In accordance with ASC 815-40, Derivatives and Hedging – Contracts in Entity’s Own Equity (“ASC 815-40”), the warrant liabilities are being marked to market until they are completely settled. The warrants are valued using the Black-Scholes method, using assumptions consistent with our application of ASC 505-50, Equity-Based Payments to Non-Employees (“ASC 505-50”). The gain or loss resulting from the marked to market calculation is shown on the Consolidated Statements of Operations as gain (loss) on warrant derivative liability. The Company recognized a gain (loss) of $2.9 million and ($8.5) million for the three-month periods ended June 30, 2013 and 2012, respectively, and a gain (loss) of $0.8 million and ($12.4) million for the six-month periods ended June 30, 2013 and 2012, respectively.

The following reflects the weighted-average assumptions for each of the six-month periods indicated:

	Six Months			Ended June 30,
	2013			2012
Risk-free interest rate		0.63	%		0.54	%
Expected dividend yield		0	%		0	%
Expected lives		2.96			3.90
Expected volatility		67.3	%		86.3	%
Warrants classified as liabilities	$	3,133,743		$	19,155,292
Gain (loss) on warrant liabilities	$	838,487		$	(12,416,358	)

The dividend yield assumption of zero is based upon the fact that the Company has never paid and presently has no intention of paying cash dividends. The risk-free interest rate used for each warrant classified as a derivative is equal to the U.S. Treasury rates in effect at June 30th. The expected lives are based on the remaining contractual lives of the related warrants at the valuation date.

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Investment in Mast Therapeutics, Inc

6 Months Ended

Jun. 30, 2013

Investment in Mast Therapeutics, Inc. [Abstract]

Investment in Mast Therapeutics, Inc.

4.  Investment in Mast Therapeutics, Inc.

On April 8, 2011, Mast Therapeutics, Inc. (formerly ADVENTRX Pharmaceuticals) completed its acquisition of SynthRx, Inc., in which the Company held a 19.1% interest. As a result of the transaction, the Company received approximately 126,000 shares of common stock of Mast Therapeutics, which it sold on October 11, 2011 for $112,200, and in June 2012, the Company received an additional 38,196 shares of common stock of Mast Therapeutics that had been held in an escrow established in connection with the acquisition, which it sold on June 6, 2012 for $17,900. In January 2013, the Company received an additional 92,566 shares, and in June 2013, an additional 47,745 shares, which were all sold in June 2013 for $60,566. If all of the development milestones under the acquisition agreement were to be achieved, the Company also would be entitled to receive up to 2.8 million additional Mast Therapeutics shares. Our former interest in SynthRx had a zero carrying value.

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CONDENSED BALANCE SHEETS (Unaudited) (Parenthetical) (USD $)	Jun. 30, 2013	Dec. 31, 2012
Stockholders' equity
Preferred Stock, par value (in dollars per share)	$ 0.01	$ 0.01
Preferred Stock, shares authorized (in shares)	5,000,000	5,000,000
Series A Junior Participating Preferred Stock, shares authorized (in shares)	25,000	25,000
Preferred Stock, shares issued (in shares)	0	0
Preferred Stock, shares outstanding (in shares)	0	0
Common stock, par value (in dollars per share)	$ 0.001	$ 0.001
Common stock, shares authorized (in shares)	250,000,000	250,000,000
Common stock, shares issued (in shares)	30,608,392	30,607,916
Common stock, shares outstanding (in shares)	30,608,392	30,607,916
Treasury stock (in shares)	118,836	90,546

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Liquidity and Capital Resources

6 Months Ended

Jun. 30, 2013

Liquidity and Capital Resources [Abstract]

Liquidity and Capital Resources

9.      Liquidity and Capital Resources

At June 30, 2013, the Company had cash and cash equivalents of approximately $11.0 million and short-term investments of $17.0 million. Management believes that the Company’s current cash on hand and short-term investments will be sufficient to fund its operations for the foreseeable future. The estimate is based, in part, upon the Company’s currently projected expenditures for the remainder of 2013 and the first six months of 2014 of approximately $20.7 million, whichincludes approximately $8.1 million for its clinical programs for aldoxorubicin, approximately $1.2 million for its clinical programs for tamibarotene and bafetinib, approximately $4.7 million for general operation of its clinical programs, and approximately $6.7 million for other general and administrative expenses. These projected expenditures are also based upon numerous other assumptions and subject to many uncertainties, and our actual expenditures may be significantly different from these projections.

If the Company obtains marketing approval and successfully commercializes its product candidates, the Company anticipates it will take severalyears, and possibly longer, for it to generate significant recurring revenue. The Company will be dependent on future financing and possible strategic partnerships or asset sales until such time, if ever, as it can generate significant recurring revenue. The Company has no commitments from third parties to provide any additional financing, and it may not be able to obtain future financing on favorable terms, or at all. If the Company fails to obtain sufficient funding when needed, it may be forced to delay, scale back or eliminate all or a portion of its development programs or clinical trials, seek to license to other companies its product candidates or technologies that it would prefer to develop and commercialize itself, or seek to sell some or all of its assets or merge with or be acquired by another company.

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CONDENSED STATEMENTS OF CASH FLOWS (Unaudited) (USD $)	6 Months Ended
	Jun. 30, 2013	Jun. 30, 2012
Cash flows from operating activities:
Net loss	$ (10,287,251)	$ (23,397,354)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	59,226	52,875
Retirement of fixed assets	0	4,360
Stock compensation and warrant expense	762,748	858,937
Fair value adjustment on warrant liability	(838,487)	12,416,358
Net foreign exchange gain	(138,709)	0
Changes in assets and liabilities:
Receivables	(101,824)	154,946
Interest receivable	(29,934)	19,105
Prepaid expenses and other current assets	631,137	102,323
Accounts payable	(278,151)	93,663
Accrued expenses and other current liabilities	(139,290)	616,083
Net cash used in operating activities	(10,360,535)	(9,078,704)
Cash flows from investing activities:
Proceeds from sale of short-term investments	7,000,000	2,989,902
Purchases of equipment and furnishings	(4,000)	(47,979)
Net cash provided by investing activities	6,996,000	2,941,923
Cash flows from financing activities:
Net proceeds from exercise of stock options	933	7,200
Net cash provided by financing activities	933	7,200
Net decrease in cash and cash equivalents	(3,363,602)	(6,129,581)
Cash and cash equivalents at beginning of period	14,344,088	17,988,590
Cash and cash equivalents at end of period	10,980,486	11,859,009
Supplemental disclosure of cash flow information:
Equipment and furnishings purchased on credit	1,529	64,022
Repurchase of Company's own stock for treasury	56,580	0
Cash paid for income taxes	$ 5,600	$ 82,110

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CONDENSED BALANCE SHEETS (Unaudited) (USD $)	Jun. 30, 2013	Dec. 31, 2012
Current assets:
Cash and cash equivalents	$ 10,980,486	$ 14,344,088
Short-term investments	17,000,000	24,000,000
Receivables	211,626	109,802
Interest receivable	56,451	26,517
Prepaid expenses and other current assets	580,904	1,212,041
Total current assets	28,829,467	39,692,448
Equipment and furnishings, net	199,580	253,277
Goodwill	183,780	183,780
Other assets	102,271	102,271
Total assets	29,315,098	40,231,776
Current liabilities:
Accounts payable	2,783,894	3,060,516
Accrued expenses and other current liabilities	2,811,770	3,033,189
Warrant liabilities	3,133,743	3,972,230
Total current liabilities	8,729,407	10,065,935
Commitments and contingencies
Stockholders' equity
Preferred Stock, $.01 par value, 5,000,000 shares authorized, including 25,000 shares of Series A Junior Participating Preferred Stock; no shares issued and outstanding	0	0
Common stock, $.001 par value, 250,000,000 shares authorized; 30,608,392 shares issued and outstanding at June 30, 2013 and 30,607,916 at December 31, 2012	30,609	30,608
Additional paid-in capital	262,082,318	261,318,638
Treasury stock, at cost (118,836 shares at June 30, 2013 and 90,546 at December 31, 2012)	(2,335,818)	(2,279,238)
Accumulated deficit	(239,191,418)	(228,904,167)
Total stockholders' equity	20,585,691	30,165,841
Total liabilities and stockholders' equity	$ 29,315,098	$ 40,231,776

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Warrant Liabilities (Details) (USD $)	3 Months Ended		6 Months Ended
	Jun. 30, 2013	Jun. 30, 2012	Jun. 30, 2013	Jun. 30, 2012	Dec. 31, 2012
Derivative [Line Items]
Warrants classified as liabilities	$ 3,133,743		$ 3,133,743		$ 3,972,230
Gain (loss) on warrant liabilities	2,933,707	(8,528,192)	838,487	(12,416,358)
Warrant [Member]
Derivative [Line Items]
Risk-free interest rate (in hundredths)			0.63%	0.54%
Expected dividend yield (in hundredths)			0.00%	0.00%
Expected lives			2 years 11 months 16 days	3 years 10 months 24 days
Expected volatility (in hundredths)			67.30%	86.30%
Warrants classified as liabilities	3,133,743	19,155,292	3,133,743	19,155,292
Gain (loss) on warrant liabilities	$ 2,900,000	$ (8,500,000)	$ 838,487	$ (12,416,358)

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Fair Value Measurements

6 Months Ended

Jun. 30, 2013

Fair Value Measurements [Abstract]

Fair Value Measurements

8. Fair Value Measurements

Assets and liabilities recorded at fair value on the balance sheets are categorized based upon the level of judgment associated with the inputs used to measure the fair value. Level inputs are as follows:

Level 1 – quoted prices in active markets for identical assets or liabilities.

Level 2 – other significant observable inputs for the assets or liabilities through corroboration with market data at the measurement date.

Level 3 – significant unobservable inputs that reflect management’s best estimate of what market participants would use to price the assets or liabilities at the measurement date.

The following table summarizes fair value measurements by level at June 30, 2013 for assets and liabilities measured at fair value on a recurring basis:

(In thousands)	Level I		Level II		Level III		Total
Cash equivalents	$	10,384	$	—	$	—	$	10,384
Short-term investments		17,000		—		—		17,000
Warrant liability		—		—		3,134		3,134

The following table summarizes fair value measurements by level at December 31, 2012 for assets and liabilities measured at fair value on a recurring basis:

(In thousands)	Level I		Level II		Level III		Total
Cash equivalents	$	13,188	$	—	$	—	$	13,188
Short-term investments		24,000		—		—		24,000
Warrant liabilities		—		—		3,972		3,972

Liabilities measured at market value on a recurring basis include warrant liabilities resulting from the Company’s July 2009 and August 2011 equity financings. In accordance with ASC 815-40, the warrant liabilities are marked to market each quarter-end until they are completely settled. The warrants are valued using the Black-Scholes method, using assumptions consistent with the Company’s application of ASC 505-50. See Warrant Liabilities above.

The Company considers carrying amounts of accounts receivable, accounts payable and accrued expenses to approximate fair value due to the short-term nature of these financial instruments.

The Company’s non-financial assets are measured at fair value when there is an indicator of impairment and recorded at fair value only when an impairment charge is recognized. The Company’s non-financial assets were not material at June 30, 2013 or 2012.

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Warrant Liabilities (Tables)

6 Months Ended

Jun. 30, 2013

Warrant Liabilities [Abstract]

Schedule of weighted-average assumptions

The following reflects the weighted-average assumptions for each of the six-month periods indicated:

	Six Months			Ended June 30,
	2013			2012
Risk-free interest rate		0.63	%		0.54	%
Expected dividend yield		0	%		0	%
Expected lives		2.96			3.90
Expected volatility		67.3	%		86.3	%
Warrants classified as liabilities	$	3,133,743		$	19,155,292
Gain (loss) on warrant liabilities	$	838,487		$	(12,416,358	)

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Stock Based Compensation

6 Months Ended

Jun. 30, 2013

Stock Based Compensation [Abstract]

Stock Based Compensation

7.  Stock Based Compensation

The Company has a 2000 Long-Term Incentive Plan. As of June 30, 2013, there were approximately 1.0 million shares subject to outstanding stock options under this plan, which expired on August 6, 2010. Thus, no further shares are available for future grant under this plan.

The Company also has a 2008 Stock Incentive Plan. As of June 30, 2013, there were 2.4 million shares subject to outstanding stock options and 2.6 million shares available for future grant under this plan.

The Company follows ASC 718, Compensation-Stock Compensation, which requires the measurement and recognition of compensation expense for all stock-based awards made to employees.

For stock options and stock warrants paid in consideration of services rendered by non-employees, the Company recognizes compensation expense in accordance with the requirements of ASC 505-50.

Non-employee option grants that do not vest immediately upon grant are recorded as an expense over the vesting period. At the end of each financial reporting period, the value of these options, as calculated using the Black-Scholes option-pricing model, is determined, and compensation expense recognized or recovered during the period is adjusted accordingly. Since the fair market value of options granted to non-employees is subject to change in the future, the amount of the future compensation expense is subject to adjustment until the common stock options are fully vested.

The following table sets forth the total stock-based compensation expense resulting from stock options and warrants included in the Company’s unaudited interim statements of operations:

	Three Months Ended June 30,				Six Months Ended June 30,
	2013		2012		2013		2012
Research and development — employee	$	53,583	$	98,242	$	103,755	$	193,366
General and administrative — employee		202,589		263,007		387,229		437,079
Total employee stock-based compensation	$	256,172	$	361,249	$	490,984	$	630,445
Research and development — non-employee	$	—	$	—	$	—	$	—
General and administrative — non-employee		152,074		176,074		179,286		228,492
Total non-employee stock-based compensation	$	152,074	$	176,074	$	179,286	$	228,492

During the six-month period ended June 30, 2013, the Company issued stock options to purchase 117,176 shares of its common stock. The fair value of the stock options granted in the current six-month period was estimated using the Black-Scholes option-pricing model, based on the following assumptions:

	Six Months Ended June 30, 2013			Six Months Ended June 30, 2012
Risk-free interest rate		1.11	%		1.54	%
Expected volatility		85.2% - 85.8	%		89.7% - 97.7	%
Expected lives (years)		6			6 - 10
Expected dividend yield		0.00	%		0.00	%

The Company’s computation of expected volatility is based on the historical daily volatility of its publicly traded stock. For option grants issued during the six-month period ended June 30, 2013, the Company used a calculated volatility for each grant. The Company uses historical information to compute expected lives. In the six-month period ended June 30, 2013, the contractual term of the options granted was ten years and the Company used six years as the expected life. The dividend yield assumption of zero is based upon the fact the Company has never paid and presently has no intention of paying cash dividends. The risk-free interest rate used for each grant is equal to the U.S. Treasury rates in effect at the time of the grant for instruments with a similar expected life. Based on historical experience, for the six-month period ended June 30, 2013, the Company has estimated an annualized forfeiture rate of 12% for options granted to its employees, 3% for options granted to senior management and 0% for options granted to directors and non-employees. For the comparative six-month period ended June 30, 2012, the Company had estimated an annualized forfeiture rate of 14% for options granted to its employees, 2% for options granted to senior management and 0% for options granted to directors and non-employees. Compensation costs will be adjusted for future changes in estimated forfeitures. The Company will record additional expense if the actual forfeitures are lower than estimated and will record a recovery of prior expense if the actual forfeiture rates are higher than estimated. No amounts relating to employee stock-based compensation have been capitalized.

As of June 30, 2013, there remained approximately $1.3 million of unrecognized compensation expense related to unvested stock options granted to current and former employees, directors and consultants, to be recognized as expense over a weighted-average period of 1.13 years. Presented below is the Company’s stock option activity:

	Six Months Ended June 30, 2013
	Number of Options (Employees)			Number of Options (Non-Employees)		Total Number of Options			Weighted-Average Exercise Price
Outstanding at January 1, 2013		3,240,850			142,143		3,382,993		$	4.17
Granted		92,176			25,000		117,176		$	2.52
Exercised		(476	)		—		(476	)	$	1.96
Forfeited or expired		(103,716	)		—		(103,716	)	$	3.08
Outstanding at June 30, 2013		3,228,834			167,143		3,395,977		$	4.15
Options exercisable at June 30, 2013		2,159,480			149,881		2,309,361		$	5.10

A summary of the unvested stock options as of June 30, 2013, and changes during the six-month period then ended, is presented below:

	Number of Options (Employees)			Number of Options (Non-Employees)			Total Number of Options			Weighted-Average Grant Date Fair Value per Share
Non-vested at January 1, 2013		1,322,389			8,929			1,331,318		$	1.69
Granted		92,176			25,000			117,176		$	1.80
Forfeited or expired		(103,716	)		—			(103,716	)	$	2.32
Vested		(241,495	)		(16,667	)		(258,162	)	$	3.68
Non-vested at June 30, 2013		1,069,354			17,262			1,086,616		$	1.67

The following table summarizes significant ranges of outstanding stock options under the Company’s plans at June 30, 2013:

Range of Exercise Prices		Number of Options		Weighted-Average Remaining Contractual Life (years)		Weighted-Average Exercise Price		Number of Options Exercisable		Weighted-Average Contractual Life		Weighted-Average Exercise Price
$	1.83 - 3.00		2,143,069		8.99	$	1.99		1,100,587		8.99	$	2.04
$	3.01 –7.00		178,512		4.77	$	5.24		176,036		4.77	$	5.26
$	7.01 –8.50		942,110		4.63	$	7.66		900,452		4.63	$	7.68
$	8.51 – 32.55		132,286		1.33	$	12.75		132,286		1.33	$	12.75
			3,395,977		7.26	$	4.15		2,309,361		7.26	$	5.10

The aggregate intrinsic value of outstanding options as of June 30, 2013 was $2.7 million, which represents options whose exercise price was less than the closing fair market value of the Company’s common stock on June 28, 2013 of $2.00.

Restricted Stock

On December 31, 2012, the Company granted to Dr. Daniel Levitt, Executive Vice President and Chief Medical Officer, 100,000 shares of CytRx Corporation restricted stock pursuant to the 2008 Plan, of which 50,000 shares vested on June 30, 2013, and the remaining 50,000 shares will vest in six subsequent monthly installments, provided that Dr. Levitt remains employed by the Company as of the end of each such month. The fair value of the restricted stock is based on the market price of the Company’s shares on the grant date less the par value received as consideration. The fair value of these restricted shares on the grant date was $186,900. The stock-based compensation expense relating to restricted stock for the three and six-months ended June 30, 2013, respectively, was $46,495 and $92,478. There was no such expense in the comparable periods of 2012.

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Recent Accounting Pronouncements

6 Months Ended

Jun. 30, 2013

Recent Accounting Pronouncements [Abstract]

Recent Accounting Pronouncements

2. Recent Accounting Pronouncements

We have reviewed all of the recent accounting pronouncements and have determined that they have not or will not have a material impact on our financial statements, or simply do not apply to our operations.

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Description of Company and Basis of Presentation (Details)	6 Months Ended
	Jun. 30, 2013 Program
Description of Company and Basis of Presentation [Abstract]
Number of programs in clinical development for cancer indications	2
Reverse stock split conversation ratio	1-for-7

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Income Taxes

6 Months Ended

Jun. 30, 2013

Income Taxes [Abstract]

Income Taxes

10. Income Taxes

The Company completed an analysis of changes in ownership and concluded the net operating loss carryforwards as of December 31, 2012 are not subject to limitation under Section 382 of the Internal Revenue Code. The Company will continue to monitor any possible changes in ownership.

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Basic and Diluted Net Loss Per Common Share (Details) In Millions, unless otherwise specified	3 Months Ended		6 Months Ended
	Jun. 30, 2013	Jun. 30, 2012	Jun. 30, 2013	Jun. 30, 2012
Basic and Diluted Net Loss Per Common Share [Abstract]
Antidilutive securities excluded from computation of earnings per share, amount (in shares)	11.2	9.6	11.2	9.6

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Short-term Investments (Details) (USD $)	Jun. 30, 2013	Dec. 31, 2012
Schedule of Available-for-sale Securities [Line Items]
Short-term investments	$ 17,000,000	$ 24,000,000
Certificates of Deposit [Member] | Maturity date of October 31, 2013 [Member]
Schedule of Available-for-sale Securities [Line Items]
Short-term investments	$ 17,000,000

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Document and Entity Information	6 Months Ended
	Jun. 30, 2013	Aug. 06, 2013
Document and Entity Information [Abstract]
Entity Registrant Name	CYTRX CORP
Entity Central Index Key	0000799698
Current Fiscal Year End Date	--12-31
Entity Well-known Seasoned Issuer	No
Entity Voluntary Filers	No
Entity Current Reporting Status	Yes
Entity Filer Category	Accelerated Filer
Entity Common Stock, Shares Outstanding		30,489,556
Document Fiscal Year Focus	2013
Document Fiscal Period Focus	Q2
Document Type	10-Q
Amendment Flag	false
Document Period End Date	Jun. 30, 2013

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Investment in Mast Therapeutics, Inc (Details) (USD $)	Jun. 30, 2013	Mar. 31, 2013	Apr. 08, 2011 SynthRx, Inc. [Member]	Jun. 30, 2013 Mast Therapeutics, Inc. [Member]	Jun. 06, 2012 Mast Therapeutics, Inc. [Member]	Oct. 11, 2011 Mast Therapeutics, Inc. [Member]	Apr. 08, 2011 Mast Therapeutics, Inc. [Member]
Schedule of Equity Method Investment [Line Items]
Equity investment, ownership percentage (in hundredths)			19.10%
Common stock received in acquiring company upon acquisition of equity method investee (in shares)							126,000
Proceeds from sale of common stock in acquiring entity					$ 17,900	$ 112,200
Additional shares of common stock held in an escrow potentially issuable (in shares)					38,196
Additional number of shares received (in shares)	47,745	92,566
Investment in Mast Therapeutics, at market	$ 60,566
Additional shares of common stock potentially issuable from development milestones, maximum (in shares)				2,800,000