8-K/A

                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D. C. 20549


                                   FORM 8-K/A
                                (Amendment No. 1)


                                 CURRENT REPORT


     Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934

       Date of report (date of earliest event reported) DECEMBER 18, 2000




                              SEPRAGEN CORPORATION
        (Exact name of small business issuer as specified in its charter)

          California                      1-14068                68-0073366
(State or other jurisdiction of   (Commission file number)   (I.R.S. Employer
incorporation or organization)                               Identification No.)

                30689 Huntwood Avenue, Hayward, California 94544
                    (Address of principal executive offices)

      (Registrant's telephone number (including area code): (510) 476-0650

(Former name, former address and former fiscal year if changed since last
report): N/A



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Item 4.  Changes in Registrant's Certifying Public Accountant

         a. Effective November 28, 2000, Sepragen Corporation accepted the
resignation of Grant Thornton LLP as the Company's independent accountants.

         b. There has been no disagreement with Grant Thornton LLP on any matter
of accounting principles or practices, financial statement disclosures, or
auditing scope or procedure.

         c. The opinion for the year ended December 31, 1998 was unqualified
except for a modification with respect to the Company's ability to continue as a
going concern and the opinion for the year ended December 31, 1999 was
unqualified.

         d. The auditors have advised the Company of reportable condition on
November 6, 2000 regarding the inadequacy of its infrastructure to meet its
statutory obligation to meet the SEC filing requirements.

         e. Effective December 18, 2000, the Company has selected Bedinger &
Company, Certified Public Accountants as its independent accountants.

         f. The Company has provided Grant Thornton LLP with a copy of the
disclosures contained herein, and has requested that it furnish the Company with
a letter addressed to the Securities and Exchange Commission stating whether it
agrees or disagrees with the statements made by the Company in compliance with
rules for form 8-K and S-K 304. The response from Grant Thornton is attached as
Exhibit 16.1.


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                                   SIGNATURES


         Pursuant to the requirements of the Securities Exchange Act of 1934 the
Registrant has caused this report to be signed on its behalf by the undersigned
duly authorized:

                                    SEPRAGEN CORPORATION



Date: December 20, 2000             By: /s/ VINIT SAXENA
                                        --------------------------------------
                                        Vinit Saxena, Chief Executive Officer,
                                        President, Principal Financial Officer
                                        and Chief Accounting Officer



                                     Page 3

EX-16.1

ACCOUNTANTS AND                         GRANT THORNTON[GRAPHIC LOGO OMITTED]
MANAGEMENT CONSULTANTS                  GRANT THORNTON LLP

The US Member Firm of
Grant Thornton International

                                                                    Exhibit 16.1

December 4, 2000

Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, DC  20549

Re:    Sepragen Corporation
       File No. 1-14068

Gentlemen:

We have read Item 4 of Form 8-K dated December 4, 2000, of Sepragen Corporation
and are in agreement with the statements contained in paragraphs 4a through 4d
and 4f. We have no basis to agree or disagree with paragraph 4e of the
registrant contained therein.

/s/ GRANT THORNTON LLP
- ----------------------
Grant Thornton LLP


150 Almaden Blvd.
P.O. Box 6779
San Jose, CA 95113
Tel:  408 275-9000
Fax:  408 275-0582