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Collaboration, License and Other Strategic Agreements (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2016
Sep. 30, 2015
Jun. 30, 2015
Jun. 30, 2016
Jun. 30, 2015
Collaborative Agreements          
Cost of product sales $ 21,937   $ 19,679 $ 40,236 $ 40,705
Velo Bio option agreement          
Collaborative Agreements          
Upfront payment for option to acquire global rights to DIF program   $ 10,000      
Payments due if the option to acquire the global rights to the DIF program is exercised       65,000  
Velo Bio option agreement | Maximum          
Collaborative Agreements          
Sales milestone payments based on annual sales milestones       250,000  
Sales milestone targets       900,000  
Velo Bio option agreement | Minimum          
Collaborative Agreements          
Sales milestone targets       $ 100,000