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Basis of Presentation and Summary of Significant Accounting Policies - Concentrations and Significant Customer Information (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2016
Dec. 31, 2015
Jun. 30, 2016
Jun. 30, 2015
Jun. 30, 2016
Jun. 30, 2015
Dec. 31, 2014
Concentrations and Significant Customer Information              
Cash, cash equivalents and investments $ 546,500   $ 546,500   $ 546,500    
Investment in institutional money market funds 19,000   19,000   19,000    
Cash and cash equivalents $ 251,110 $ 228,705 $ 251,110 $ 89,884 $ 251,110 $ 89,884 $ 119,296
Sales Revenue, Net | Minimum              
Concentrations and Significant Customer Information              
Concentration risk (as a percent)     10.00% 10.00% 10.00% 10.00%  
Sales Revenue, Net | Customer Concentration Risk | Amerisource Bergen Drug Corporation              
Concentrations and Significant Customer Information              
Concentration risk (as a percent)     22.00% 19.00% 23.00% 24.00%  
Sales Revenue, Net | Customer Concentration Risk | Caremark LLC (Specialty Pharmacy)              
Concentrations and Significant Customer Information              
Concentration risk (as a percent)     10.00%   10.00%    
Sales Revenue, Net | Customer Concentration Risk | Caremark LLC (Specialty Pharmacy) | Maximum              
Concentrations and Significant Customer Information              
Concentration risk (as a percent)       10.00%   10.00%  
Sales Revenue, Net | Customer Concentration Risk | McKesson Corporation              
Concentrations and Significant Customer Information              
Concentration risk (as a percent)           10.00%  
Sales Revenue, Net | Customer Concentration Risk | McKesson Corporation | Maximum              
Concentrations and Significant Customer Information              
Concentration risk (as a percent)     10.00% 10.00% 10.00%    
Sales Revenue, Net | Customer Concentration Risk | Takeda Pharmaceutical Company Limited              
Concentrations and Significant Customer Information              
Concentration risk (as a percent)       32.00%   24.00%  
Sales Revenue, Net | Geographic Concentration Risk              
Concentrations and Significant Customer Information              
Approximate percentage of revenues from customers outside the U.S.           24.00%  
Accounts Receivable | Maximum              
Concentrations and Significant Customer Information              
Concentration risk (as a percent)     10.00% 10.00% 10.00% 10.00%  
Accounts Receivable | Credit Concentration Risk | Amerisource Bergen Drug Corporation              
Concentrations and Significant Customer Information              
Concentration risk (as a percent) 13.00% 43.00%          
Accounts Receivable | Credit Concentration Risk | Caremark LLC (Specialty Pharmacy)              
Concentrations and Significant Customer Information              
Concentration risk (as a percent) 11.00%            
Accounts Receivable | Credit Concentration Risk | Caremark LLC (Specialty Pharmacy) | Maximum              
Concentrations and Significant Customer Information              
Concentration risk (as a percent)   10.00%