Equity-Based Compensation (Tables)

6 Months Ended

Jun. 30, 2016

Schedule of equity-based compensation expense

Equity‑based compensation expense for the three and six months ended June 30, 2016 and 2015 consisted of the following (in thousands):

	Three Months Ended June 30,				Six Months Ended June 30,
	2016		2015		2016		2015
Cost of product sales	$	(44)	$	54	$	277	$	95
Research and development		968		565		1,725		1,043
Selling, general and administrative		4,254		3,397		9,339		5,546
Total equity-based compensation expense	$	5,178	$	4,016	$	11,341	$	6,684
Income tax effect		(1,394)		(1,558)		(3,068)		(2,593)
After-tax effect of equity-based compensation expense	$	3,784	$	2,458	$	8,273	$	4,091

Equity Compensation Plans

Summary of details regarding stock options granted under equity incentive plans

	2007 Equity	2000 Equity	2013 Lumara	Inducement
	Plan	Plan	Equity Plan	Grants	Total
Outstanding at December 31, 2015	1,963,162	14,040	96,000	830,975	2,904,177
Granted	495,409	—	—	80,000	575,409
Exercised	(47,937)	—	—	—	(47,937)
Expired or terminated	(152,702)	—	(41,719)	(69,250)	(263,671)
Outstanding at June 30, 2016	2,257,932	14,040	54,281	841,725	3,167,978

Summary of details regarding restricted stock units granted under equity incentive plans

	2007 Equity	2000 Equity	2013 Lumara	Inducement
	Plan	Plan	Equity Plan	Grants	Total
Outstanding at December 31, 2015	446,330	—	52,350	155,675	654,355
Granted	641,826	—	—	52,000	693,826
Vested	(186,521)	—	(16,749)	(43,998)	(247,268)
Expired or terminated	(68,704)	—	(7,571)	(5,500)	(81,775)
Outstanding at June 30, 2016	832,931	—	28,030	158,177	1,019,138