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Collaboration, License and Other Strategic Agreements (Details) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2016
Sep. 30, 2015
Mar. 31, 2015
Dec. 31, 2015
Collaborative Agreements        
Cost of product sales $ 18,300   $ 21,026  
Deferred revenues, long-term 7,659     $ 5,093
Velo Bio option agreement        
Collaborative Agreements        
Upfront payment for option to acquire global rights to DIF program   $ 10,000    
Payments due if the option to acquire the global rights to the DIF program is exercised 65,000      
Velo Bio option agreement | Maximum        
Collaborative Agreements        
Sales milestone payments based on annual sales milestones 250,000      
Sales milestone targets 900,000      
Velo Bio option agreement | Minimum        
Collaborative Agreements        
Sales milestone targets $ 100,000