CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Cash flows from operating activities:
Net income (loss)	$ (7,527)	$ 12,904
Adjustments to reconcile net income ( loss) to net cash provided by (used in) operating activities:
Depreciation and amortization	19,644	14,519
Amortization of premium/discount on purchased securities	177	56
Non-cash equity-based compensation expense	6,160	2,668
Amortization of debt discount and debt issuance costs	2,937	2,401
Change in fair value of contingent consideration	5,056	2,599
Deferred income taxes	(1,469)	5,608
Changes in operating assets and liabilities:
Accounts receivable, net	2,924	(18,004)
Inventories	(2,157)	3,326
Receivable from collaboration	246	4,518
Prepaid and other current assets	(3,078)	3,076
Accounts payable and accrued expenses	(6,647)	4,852
Deferred revenues	9,717	(10,813)
Other assets and liabilities	593	1,686
Net cash provided by operating activities	26,576	29,396
Cash flows from investing activities:
Proceeds from sales or maturities of investments	25,500	1,459
Purchase of investments	(63,413)	(93,895)
Capital expenditures, net of proceeds from sale of assets	(681)	(55)
Net cash (used in) investing activities	(38,594)	(92,491)
Cash flows from financing activities:
Proceeds from the issuance of common stock, net of underwriting discounts and other expenses		189,150
Long-term debt principal payments	(4,375)	(8,185)
Payment of contingent consideration	(65)	(84)
Payments for repurchases of common stock	(7,562)
Proceeds from the exercise of stock options	400	6,719
Payments of employee tax withholding related to equity-based compensation	(1,696)
Net cash (used in) provided by financing activities	(13,298)	187,600
Net (decrease) increase in cash and cash equivalents	(25,316)	124,505
Cash and cash equivalents at beginning of the period	228,705	119,296
Cash and cash equivalents at end of the period	203,389	243,801
Supplemental data of cash flow information:
Cash paid for taxes	2,400	238
Cash paid for interest	27,964	$ 8,880
Lumara Health
Adjustments to reconcile net income ( loss) to net cash provided by (used in) operating activities:
Change in fair value of contingent consideration	4,700
MuGard
Adjustments to reconcile net income ( loss) to net cash provided by (used in) operating activities:
Change in fair value of contingent consideration	$ (400)