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Fair Value Measurements - Contingent Consideration (Details) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Nov. 12, 2014
Reconciliation of contingent consideration obligations related to acquisitions      
Adjustments to fair value of contingent consideration $ 5,056 $ 2,599  
Lumara Health and MuGard Rights | Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 3      
Reconciliation of contingent consideration obligations related to acquisitions      
Balance at beginning of period 222,559    
Payments made (65)    
Adjustments to fair value of contingent consideration 5,056    
Balance at end of period 227,550    
Lumara Health      
Reconciliation of contingent consideration obligations related to acquisitions      
Acquisition-related contingent consideration     $ 205,000
Adjustments to fair value of contingent consideration 4,700    
Estimated undiscounted milestone amounts payable 350,000    
Contingent consideration classified as short term liability $ 97,500    
Interest rate (as a percent) 5.00%    
MuGard      
Reconciliation of contingent consideration obligations related to acquisitions      
Adjustments to fair value of contingent consideration $ (400)    
Period over which estimated undiscounted royalty amounts could be paid 10 years    
Discount rate (as a percent) 9.00%    
Contingent consideration classified as short term liability $ 900    
MuGard | Minimum      
Reconciliation of contingent consideration obligations related to acquisitions      
Estimated undiscounted royalty amounts payable 9,000    
MuGard | Maximum      
Reconciliation of contingent consideration obligations related to acquisitions      
Estimated undiscounted royalty amounts payable $ 13,000