Equity-Based Compensation (Tables)

3 Months Ended

Mar. 31, 2016

Schedule of equity-based compensation expense

Equity‑based compensation expense for the three months ended March 31, 2016 and 2015 consisted of the following (in thousands):

	Three Months Ended March 31,
	2016		2015
Cost of product sales	$	320	$	41
Research and development		756		478
Selling, general and administrative		5,084		2,149
Total equity-based compensation expense	$	6,160	$	2,668
Income tax effect		(1,674)		(1,035)
After-tax effect of equity-based compensation expense	$	4,486	$	1,633

Equity Compensation Plans

Summary of details regarding stock options granted under equity incentive plans

	2007 Equity	2000 Equity	2013 Lumara	Inducement
	Plan	Plan	Equity Plan	Grants	Total
Outstanding at December 31, 2015	1,963,162	14,040	96,000	830,975	2,904,177
Granted	334,000	—	—	45,000	379,000
Exercised	(25,315)	—	—	—	(25,315)
Expired or terminated	(96,878)	—	(30,000)	(38,000)	(164,878)
Outstanding at March 31, 2016	2,174,969	14,040	66,000	837,975	3,092,984

Summary of details regarding restricted stock units granted under equity incentive plans

	2007 Equity	2000 Equity	2013 Lumara	Inducement
	Plan	Plan	Equity Plan	Grants	Total
Outstanding at December 31, 2015	446,330	—	52,350	155,675	654,355
Granted	599,300	—	—	32,000	631,300
Vested	(175,971)	—	(16,749)	(5,000)	(197,720)
Expired or terminated	(36,364)	—	(4,235)	(2,500)	(43,099)
Outstanding at March 31, 2016	833,295	—	31,366	180,175	1,044,836